Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives

Quorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective pressure involved in antibacterial treatments. Thi...

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Main Authors:	Jianwei Chen, Bixia Wang, Yaojia Lu, Yuqi Guo, Jiadong Sun, Bin Wei, Huawei Zhang, Hong Wang
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Marine Drugs
Subjects:	quorum sensing quorum sensing inhibitor marine microorganism derivatives
Online Access:	https://www.mdpi.com/1660-3397/17/2/80

id	doaj-b276ec221f5e40eb8982c0fa275cc91a
record_format	Article
spelling	doaj-b276ec221f5e40eb8982c0fa275cc91a2020-11-24T21:46:32ZengMDPI AGMarine Drugs1660-33972019-01-011728010.3390/md17020080md17020080Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic DerivativesJianwei Chen0Bixia Wang1Yaojia Lu2Yuqi Guo3Jiadong Sun4Bin Wei5Huawei Zhang6Hong Wang7College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20878, USACollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaQuorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective pressure involved in antibacterial treatments. This review covers a series of molecules showing quorum sensing (QS) inhibitory activity that are isolated from marine microorganisms, including bacteria, actinomycetes and fungi, and chemically synthesized based on QSIs derived from marine microorganisms. This is the first comprehensive overview of QSIs derived from marine microorganisms and their synthetic analogues with QS inhibitory activity.https://www.mdpi.com/1660-3397/17/2/80quorum sensingquorum sensing inhibitormarine microorganismderivatives
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jianwei Chen Bixia Wang Yaojia Lu Yuqi Guo Jiadong Sun Bin Wei Huawei Zhang Hong Wang
spellingShingle	Jianwei Chen Bixia Wang Yaojia Lu Yuqi Guo Jiadong Sun Bin Wei Huawei Zhang Hong Wang Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives Marine Drugs quorum sensing quorum sensing inhibitor marine microorganism derivatives
author_facet	Jianwei Chen Bixia Wang Yaojia Lu Yuqi Guo Jiadong Sun Bin Wei Huawei Zhang Hong Wang
author_sort	Jianwei Chen
title	Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives
title_short	Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives
title_full	Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives
title_fullStr	Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives
title_full_unstemmed	Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives
title_sort	quorum sensing inhibitors from marine microorganisms and their synthetic derivatives
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2019-01-01
description	Quorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective pressure involved in antibacterial treatments. This review covers a series of molecules showing quorum sensing (QS) inhibitory activity that are isolated from marine microorganisms, including bacteria, actinomycetes and fungi, and chemically synthesized based on QSIs derived from marine microorganisms. This is the first comprehensive overview of QSIs derived from marine microorganisms and their synthetic analogues with QS inhibitory activity.
topic	quorum sensing quorum sensing inhibitor marine microorganism derivatives
url	https://www.mdpi.com/1660-3397/17/2/80
work_keys_str_mv	AT jianweichen quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives AT bixiawang quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives AT yaojialu quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives AT yuqiguo quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives AT jiadongsun quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives AT binwei quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives AT huaweizhang quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives AT hongwang quorumsensinginhibitorsfrommarinemicroorganismsandtheirsyntheticderivatives
_version_	1725901553892589568

Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives

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