The oncogenic role of Jagged1/Notch signaling in cancer

• Main Authors: Meng-xi Xiu, Yuan-meng Liu, Bo-hai Kuang
• Format: Article
• Language: English
• Published: Elsevier 2020-09-01
• Series: Biomedicine & Pharmacotherapy
• Subjects: JAG1; Notch; Oncogenic; Therapy; Cancer
• Online Access: http://www.sciencedirect.com/science/article/pii/S0753332220306090

Aberrant activation of Notch signaling plays an oncogenic role in cancer development. Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell interactions. JAG1 overexpression has been reported in many different types of cancer and correlates with a poor clinical prognosis. JAG1/Notch signaling controls oncogenic processes in different cell types and cellular contexts. Furthermore, JAG1/Notch signaling cascades activate a number of oncogenic factors that regulate cellular functions such as proliferation, metastasis, drug-resistance, and angiogenesis. To suppress the severe toxicity of pan-Notch inhibitors, JAG1 is attracting increasing attention as a source of therapeutic targets for cancers. In this review, the oncogenic role of JAG1/Notch signaling in cancer is discussed, as well as implications of strategies to inhibit JAG1/Notch signaling activity.