The oncogenic role of Jagged1/Notch signaling in cancer
Aberrant activation of Notch signaling plays an oncogenic role in cancer development. Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell interactions. JAG1 overexpression has been reported in many different types of cancer and correlates with a poor clinical...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-09-01
|
Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332220306090 |
id |
doaj-b2782e396af84cb3a6a1fc9d4975db77 |
---|---|
record_format |
Article |
spelling |
doaj-b2782e396af84cb3a6a1fc9d4975db772021-05-20T07:42:42ZengElsevierBiomedicine & Pharmacotherapy0753-33222020-09-01129110416The oncogenic role of Jagged1/Notch signaling in cancerMeng-xi Xiu0Yuan-meng Liu1Bo-hai Kuang2Medical School of Nanchang University, 603 Bayi Road, Nanchang, Jiangxi 330006, ChinaMedical School of Nanchang University, 603 Bayi Road, Nanchang, Jiangxi 330006, ChinaCorresponding author.; Medical School of Nanchang University, 603 Bayi Road, Nanchang, Jiangxi 330006, ChinaAberrant activation of Notch signaling plays an oncogenic role in cancer development. Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell interactions. JAG1 overexpression has been reported in many different types of cancer and correlates with a poor clinical prognosis. JAG1/Notch signaling controls oncogenic processes in different cell types and cellular contexts. Furthermore, JAG1/Notch signaling cascades activate a number of oncogenic factors that regulate cellular functions such as proliferation, metastasis, drug-resistance, and angiogenesis. To suppress the severe toxicity of pan-Notch inhibitors, JAG1 is attracting increasing attention as a source of therapeutic targets for cancers. In this review, the oncogenic role of JAG1/Notch signaling in cancer is discussed, as well as implications of strategies to inhibit JAG1/Notch signaling activity.http://www.sciencedirect.com/science/article/pii/S0753332220306090JAG1NotchOncogenicTherapyCancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meng-xi Xiu Yuan-meng Liu Bo-hai Kuang |
spellingShingle |
Meng-xi Xiu Yuan-meng Liu Bo-hai Kuang The oncogenic role of Jagged1/Notch signaling in cancer Biomedicine & Pharmacotherapy JAG1 Notch Oncogenic Therapy Cancer |
author_facet |
Meng-xi Xiu Yuan-meng Liu Bo-hai Kuang |
author_sort |
Meng-xi Xiu |
title |
The oncogenic role of Jagged1/Notch signaling in cancer |
title_short |
The oncogenic role of Jagged1/Notch signaling in cancer |
title_full |
The oncogenic role of Jagged1/Notch signaling in cancer |
title_fullStr |
The oncogenic role of Jagged1/Notch signaling in cancer |
title_full_unstemmed |
The oncogenic role of Jagged1/Notch signaling in cancer |
title_sort |
oncogenic role of jagged1/notch signaling in cancer |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2020-09-01 |
description |
Aberrant activation of Notch signaling plays an oncogenic role in cancer development. Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell interactions. JAG1 overexpression has been reported in many different types of cancer and correlates with a poor clinical prognosis. JAG1/Notch signaling controls oncogenic processes in different cell types and cellular contexts. Furthermore, JAG1/Notch signaling cascades activate a number of oncogenic factors that regulate cellular functions such as proliferation, metastasis, drug-resistance, and angiogenesis. To suppress the severe toxicity of pan-Notch inhibitors, JAG1 is attracting increasing attention as a source of therapeutic targets for cancers. In this review, the oncogenic role of JAG1/Notch signaling in cancer is discussed, as well as implications of strategies to inhibit JAG1/Notch signaling activity. |
topic |
JAG1 Notch Oncogenic Therapy Cancer |
url |
http://www.sciencedirect.com/science/article/pii/S0753332220306090 |
work_keys_str_mv |
AT mengxixiu theoncogenicroleofjagged1notchsignalingincancer AT yuanmengliu theoncogenicroleofjagged1notchsignalingincancer AT bohaikuang theoncogenicroleofjagged1notchsignalingincancer AT mengxixiu oncogenicroleofjagged1notchsignalingincancer AT yuanmengliu oncogenicroleofjagged1notchsignalingincancer AT bohaikuang oncogenicroleofjagged1notchsignalingincancer |
_version_ |
1721434918993526784 |