A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
Alternative RNA splicing varies across the brain. Its mapping at single cell resolution is unclear. Here, the authors provide a spatial and single-cell splicing atlas reporting brain region- and cell type-specific expression of different isoforms in the postnatal mouse brain.
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| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20343-5 |
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doaj-b27a2afb47544e009093959c837b41e32021-01-24T12:12:41ZengNature Publishing GroupNature Communications2041-17232021-01-0112111610.1038/s41467-020-20343-5A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brainAnoushka Joglekar0Andrey Prjibelski1Ahmed Mahfouz2Paul Collier3Susan Lin4Anna Katharina Schlusche5Jordan Marrocco6Stephen R. Williams7Bettina Haase8Ashley Hayes9Jennifer G. Chew10Neil I. Weisenfeld11Man Ying Wong12Alexander N. Stein13Simon A. Hardwick14Toby Hunt15Qi Wang16Christoph Dieterich17Zachary Bent18Olivier Fedrigo19Steven A. Sloan20Davide Risso21Erich D. Jarvis22Paul Flicek23Wenjie Luo24Geoffrey S. Pitt25Adam Frankish26August B. Smit27M. Elizabeth Ross28Hagen U. Tilgner29Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell MedicineCenter for Algorithmic Biotechnology, Institute of Translational Biomedicine, St. Petersburg State UniversityDepartment of Human Genetics, Leiden University Medical CenterBrain and Mind Research Institute and Center for Neurogenetics, Weill Cornell MedicineGraduate Program in Neuroscience, Weill Cornell Medical CollegeBrain and Mind Research Institute and Center for Neurogenetics, Weill Cornell MedicineHarold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University10x GenomicsThe Vertebrate Genomes Lab, The Rockefeller University10x Genomics10x Genomics10x GenomicsBrain and Mind Research Institute and Appel Alzheimer’s Research Institute, Weill Cornell MedicineSchool of General Studies, Columbia UniversityBrain and Mind Research Institute and Center for Neurogenetics, Weill Cornell MedicineEuropean Molecular Biology Laboratory, European Bioinformatics InstituteSection of Bioinformatics and Systems Cardiology, University HospitalSection of Bioinformatics and Systems Cardiology, University Hospital10x GenomicsThe Vertebrate Genomes Lab, The Rockefeller UniversityDepartment of Human Genetics, Emory University School of MedicineDepartment of Statistical Sciences, University of PadovaThe Vertebrate Genomes Lab, The Rockefeller UniversityEuropean Molecular Biology Laboratory, European Bioinformatics InstituteBrain and Mind Research Institute and Appel Alzheimer’s Research Institute, Weill Cornell MedicineGraduate Program in Neuroscience, Weill Cornell Medical CollegeEuropean Molecular Biology Laboratory, European Bioinformatics InstituteDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU UniversityBrain and Mind Research Institute and Center for Neurogenetics, Weill Cornell MedicineBrain and Mind Research Institute and Center for Neurogenetics, Weill Cornell MedicineAlternative RNA splicing varies across the brain. Its mapping at single cell resolution is unclear. Here, the authors provide a spatial and single-cell splicing atlas reporting brain region- and cell type-specific expression of different isoforms in the postnatal mouse brain.https://doi.org/10.1038/s41467-020-20343-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Anoushka Joglekar Andrey Prjibelski Ahmed Mahfouz Paul Collier Susan Lin Anna Katharina Schlusche Jordan Marrocco Stephen R. Williams Bettina Haase Ashley Hayes Jennifer G. Chew Neil I. Weisenfeld Man Ying Wong Alexander N. Stein Simon A. Hardwick Toby Hunt Qi Wang Christoph Dieterich Zachary Bent Olivier Fedrigo Steven A. Sloan Davide Risso Erich D. Jarvis Paul Flicek Wenjie Luo Geoffrey S. Pitt Adam Frankish August B. Smit M. Elizabeth Ross Hagen U. Tilgner |
| spellingShingle |
Anoushka Joglekar Andrey Prjibelski Ahmed Mahfouz Paul Collier Susan Lin Anna Katharina Schlusche Jordan Marrocco Stephen R. Williams Bettina Haase Ashley Hayes Jennifer G. Chew Neil I. Weisenfeld Man Ying Wong Alexander N. Stein Simon A. Hardwick Toby Hunt Qi Wang Christoph Dieterich Zachary Bent Olivier Fedrigo Steven A. Sloan Davide Risso Erich D. Jarvis Paul Flicek Wenjie Luo Geoffrey S. Pitt Adam Frankish August B. Smit M. Elizabeth Ross Hagen U. Tilgner A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain Nature Communications |
| author_facet |
Anoushka Joglekar Andrey Prjibelski Ahmed Mahfouz Paul Collier Susan Lin Anna Katharina Schlusche Jordan Marrocco Stephen R. Williams Bettina Haase Ashley Hayes Jennifer G. Chew Neil I. Weisenfeld Man Ying Wong Alexander N. Stein Simon A. Hardwick Toby Hunt Qi Wang Christoph Dieterich Zachary Bent Olivier Fedrigo Steven A. Sloan Davide Risso Erich D. Jarvis Paul Flicek Wenjie Luo Geoffrey S. Pitt Adam Frankish August B. Smit M. Elizabeth Ross Hagen U. Tilgner |
| author_sort |
Anoushka Joglekar |
| title |
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain |
| title_short |
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain |
| title_full |
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain |
| title_fullStr |
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain |
| title_full_unstemmed |
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain |
| title_sort |
spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Alternative RNA splicing varies across the brain. Its mapping at single cell resolution is unclear. Here, the authors provide a spatial and single-cell splicing atlas reporting brain region- and cell type-specific expression of different isoforms in the postnatal mouse brain. |
| url |
https://doi.org/10.1038/s41467-020-20343-5 |
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