Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report
Background Drug-induced liver injury is a common cause of transaminitis, occurring in up to 5% of patients who are hospitalized for liver failure. In pregnancy, transaminitis is seen in conditions which may require expedited delivery. Case A 39-year-old G2P0010 at 272/7 weeks' gestat...
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2020-07-01
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doaj-b27fba873fa74a8db18787e24f0fec0c2020-11-25T01:22:58ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052020-07-011003e210e21210.1055/s-0040-1713789Labetalol-Induced Hepatotoxicity during Pregnancy: A Case ReportAnna Whelan0Joanna Izewski1Charles Berkelhammer2Jami Walloch3Helen H. Kay4Department of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, Chicago, IllinoisDepartment of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, Chicago, IllinoisDepartment of Gastroenterology, Advocate Christ Medicine Center, Oak Lawn, IllinoisDepartment of Pathology, Advocate Christ Medical Center, Oak Lawn, IllinoisDepartment of Maternal-Fetal Medicine, Advocate Christ Medical Center, Oak Lawn, IllinoisBackground Drug-induced liver injury is a common cause of transaminitis, occurring in up to 5% of patients who are hospitalized for liver failure. In pregnancy, transaminitis is seen in conditions which may require expedited delivery. Case A 39-year-old G2P0010 at 272/7 weeks' gestation with chronic hypertension on labetalol was found to have elevated transaminases. Evaluation for preeclampsia, acute fatty liver, nonalcoholic steatohepatitis, cholelithiasis, infections, and autoimmune conditions were all negative. Labetalol was then discontinued, and liver biopsy was performed. After discontinuation of labetalol, her hepatitis improved, and she was discharged on hospital day 12 and went on to deliver at term. Conclusion Labetalol-induced hepatitis should be considered in the differential for transaminitis during pregnancy to prevent iatrogenic preterm delivery.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1713789labetalolhypertension in pregnancyhepatotoxicitytransaminitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Whelan Joanna Izewski Charles Berkelhammer Jami Walloch Helen H. Kay |
spellingShingle |
Anna Whelan Joanna Izewski Charles Berkelhammer Jami Walloch Helen H. Kay Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report American Journal of Perinatology Reports labetalol hypertension in pregnancy hepatotoxicity transaminitis |
author_facet |
Anna Whelan Joanna Izewski Charles Berkelhammer Jami Walloch Helen H. Kay |
author_sort |
Anna Whelan |
title |
Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report |
title_short |
Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report |
title_full |
Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report |
title_fullStr |
Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report |
title_full_unstemmed |
Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report |
title_sort |
labetalol-induced hepatotoxicity during pregnancy: a case report |
publisher |
Thieme Medical Publishers, Inc. |
series |
American Journal of Perinatology Reports |
issn |
2157-6998 2157-7005 |
publishDate |
2020-07-01 |
description |
Background Drug-induced liver injury is a common cause of transaminitis, occurring in up to 5% of patients who are hospitalized for liver failure. In pregnancy, transaminitis is seen in conditions which may require expedited delivery.
Case A 39-year-old G2P0010 at 272/7 weeks' gestation with chronic hypertension on labetalol was found to have elevated transaminases. Evaluation for preeclampsia, acute fatty liver, nonalcoholic steatohepatitis, cholelithiasis, infections, and autoimmune conditions were all negative. Labetalol was then discontinued, and liver biopsy was performed. After discontinuation of labetalol, her hepatitis improved, and she was discharged on hospital day 12 and went on to deliver at term.
Conclusion Labetalol-induced hepatitis should be considered in the differential for transaminitis during pregnancy to prevent iatrogenic preterm delivery. |
topic |
labetalol hypertension in pregnancy hepatotoxicity transaminitis |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1713789 |
work_keys_str_mv |
AT annawhelan labetalolinducedhepatotoxicityduringpregnancyacasereport AT joannaizewski labetalolinducedhepatotoxicityduringpregnancyacasereport AT charlesberkelhammer labetalolinducedhepatotoxicityduringpregnancyacasereport AT jamiwalloch labetalolinducedhepatotoxicityduringpregnancyacasereport AT helenhkay labetalolinducedhepatotoxicityduringpregnancyacasereport |
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