Role of biomaterials in neurorestoration after spinal cord injuries
Despite advances in knowledge and technology SCI remains one of the most severe and disabling disorders affecting young people. Spinal cord lesions result in permanent loss of motor, sensory and autonomic functions, causing an enormous impact on patient’s personal, social, familial and professional...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Romanian Association of Balneology, Editura Balneara
2016-05-01
|
Series: | Balneo Research Journal |
Subjects: | |
Online Access: | http://bioclima.ro/balneo118.pdf |
id |
doaj-b283365e40124cda899d6f8f3a3a3458 |
---|---|
record_format |
Article |
spelling |
doaj-b283365e40124cda899d6f8f3a3a34582020-11-24T20:42:41ZengRomanian Association of Balneology, Editura BalnearaBalneo Research Journal2069-75972069-76192016-05-0172555910.12680/balneo.2016.118Role of biomaterials in neurorestoration after spinal cord injuriesIoana Stanescu0Gabriela Dogaru11. University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj – Neuroscience Department2. University of Medicine and Pharmacy “Iuliu Hatieganu” – Medical Rehabilitation and Physical Medicine DepartmentDespite advances in knowledge and technology SCI remains one of the most severe and disabling disorders affecting young people. Spinal cord lesions result in permanent loss of motor, sensory and autonomic functions, causing an enormous impact on patient’s personal, social, familial and professional life. There is currently no effective treatment available to improve severe neurologic deficits and to decrease disability. Tissue-engineering techniques have developed a variety of scaffolds, made by biomaterials, used alone, incapsulated with cells or embedded with molecules, which are delivered to lesion site to achieve neural regeneration. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Biomaterials acts like cell-carriers for the injury site, but also as reservoirs for growth factors or biomolecules. Hydrogels are a promising therapeutical strategy in spinal cord repair. Nano-fibers provide a three-dimensional network, which mimic closely the native extracellular matrix, thus offering a better support for cell attachment and proliferation than traditional micro-structure. New strategies like pharmacologic treatments, cell therapies, gene therapies and biomaterial tissue engineering should combine to increase their synergistic effect and to obtain the expected functional recovery in spinal cord injured patients http://bioclima.ro/balneo118.pdfspinal cord injurybiomaterialsneuroregenerationcombinatorial approach |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ioana Stanescu Gabriela Dogaru |
spellingShingle |
Ioana Stanescu Gabriela Dogaru Role of biomaterials in neurorestoration after spinal cord injuries Balneo Research Journal spinal cord injury biomaterials neuroregeneration combinatorial approach |
author_facet |
Ioana Stanescu Gabriela Dogaru |
author_sort |
Ioana Stanescu |
title |
Role of biomaterials in neurorestoration after spinal cord injuries |
title_short |
Role of biomaterials in neurorestoration after spinal cord injuries |
title_full |
Role of biomaterials in neurorestoration after spinal cord injuries |
title_fullStr |
Role of biomaterials in neurorestoration after spinal cord injuries |
title_full_unstemmed |
Role of biomaterials in neurorestoration after spinal cord injuries |
title_sort |
role of biomaterials in neurorestoration after spinal cord injuries |
publisher |
Romanian Association of Balneology, Editura Balneara |
series |
Balneo Research Journal |
issn |
2069-7597 2069-7619 |
publishDate |
2016-05-01 |
description |
Despite advances in knowledge and technology SCI remains one of the most severe and disabling disorders affecting young people. Spinal cord lesions result in permanent loss of motor, sensory and autonomic functions, causing an enormous impact on patient’s personal, social, familial and professional life. There is currently no effective treatment available to improve severe neurologic deficits and to decrease disability.
Tissue-engineering techniques have developed a variety of scaffolds, made by biomaterials, used alone, incapsulated with cells or embedded with molecules, which are delivered to lesion site to achieve neural regeneration.
Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Biomaterials acts like cell-carriers for the injury site, but also as reservoirs for growth factors or biomolecules. Hydrogels are a promising therapeutical strategy in spinal cord repair. Nano-fibers provide a three-dimensional network, which mimic closely the native extracellular matrix, thus offering a better support for cell attachment and proliferation than traditional micro-structure.
New strategies like pharmacologic treatments, cell therapies, gene therapies and biomaterial tissue engineering should combine to increase their synergistic effect and to obtain the expected functional recovery in spinal cord injured patients
|
topic |
spinal cord injury biomaterials neuroregeneration combinatorial approach |
url |
http://bioclima.ro/balneo118.pdf |
work_keys_str_mv |
AT ioanastanescu roleofbiomaterialsinneurorestorationafterspinalcordinjuries AT gabrieladogaru roleofbiomaterialsinneurorestorationafterspinalcordinjuries |
_version_ |
1716822044127002624 |