Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage

Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage

Show other versions (1)

The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid tryptophan, leading to the production of several neuroactive and immunoregulatory metabolites. Alterations in the KP have been implicated in various neuropsychiatric and neurodegenerative diseases, immunolog...

Full description

Bibliographic Details
Main Authors: Diba Sheipouri, Nady Braidy, Gilles J. Guillemin
Format: Article
Language:English
Published: SAGE Publishing 2012-01-01
Series:International Journal of Tryptophan Research
Online Access:https://doi.org/10.4137/IJTR.S9835
id doaj-b2a8ea3c4e6145408dd7a7b0dab314e8
record_format Article
spelling doaj-b2a8ea3c4e6145408dd7a7b0dab314e82020-11-25T03:15:47ZengSAGE PublishingInternational Journal of Tryptophan Research1178-64692012-01-01510.4137/IJTR.S9835Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin DamageDiba Sheipouri0Nady Braidy1Gilles J. Guillemin2University of New South Wales, School of Medical Sciences, Dept of Pharmacology, Sydney, Australia.University of New South Wales, School of Psychiatry, Sydney, Australia.St. Vincent's Centre for Applied Medical Research, Sydney, Australia.The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid tryptophan, leading to the production of several neuroactive and immunoregulatory metabolites. Alterations in the KP have been implicated in various neuropsychiatric and neurodegenerative diseases, immunological disorders, and many other diseased states. Although the role of the KP in the skin has been evaluated in small niche fields, limited studies are available regarding the effect of acute ultra violet exposure and the induction of the KP in human skin-derived fibroblasts and keratinocytes. Since UV exposure can illicit an inflammatory component in skin cells, it is highly likely that the KP may be induced in these cells in response to UV exposure. It is also possible that some KP metabolites may act as pro-inflammatory and anti-inflammatory mediators, since the KP is important in immunomodulation.https://doi.org/10.4137/IJTR.S9835
collection DOAJ
language English
format Article
sources DOAJ
author Diba Sheipouri
Nady Braidy
Gilles J. Guillemin
spellingShingle Diba Sheipouri
Nady Braidy
Gilles J. Guillemin
Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
International Journal of Tryptophan Research
author_facet Diba Sheipouri
Nady Braidy
Gilles J. Guillemin
author_sort Diba Sheipouri
title Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
title_short Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
title_full Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
title_fullStr Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
title_full_unstemmed Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
title_sort kynurenine pathway in skin cells: implications for uv-induced skin damage
publisher SAGE Publishing
series International Journal of Tryptophan Research
issn 1178-6469
publishDate 2012-01-01
description The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid tryptophan, leading to the production of several neuroactive and immunoregulatory metabolites. Alterations in the KP have been implicated in various neuropsychiatric and neurodegenerative diseases, immunological disorders, and many other diseased states. Although the role of the KP in the skin has been evaluated in small niche fields, limited studies are available regarding the effect of acute ultra violet exposure and the induction of the KP in human skin-derived fibroblasts and keratinocytes. Since UV exposure can illicit an inflammatory component in skin cells, it is highly likely that the KP may be induced in these cells in response to UV exposure. It is also possible that some KP metabolites may act as pro-inflammatory and anti-inflammatory mediators, since the KP is important in immunomodulation.
url https://doi.org/10.4137/IJTR.S9835
work_keys_str_mv AT dibasheipouri kynureninepathwayinskincellsimplicationsforuvinducedskindamage
AT nadybraidy kynureninepathwayinskincellsimplicationsforuvinducedskindamage
AT gillesjguillemin kynureninepathwayinskincellsimplicationsforuvinducedskindamage
_version_ 1724637588989411328

Similar Items