A molecular portrait of microsatellite instability across multiple cancers

Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to identify patients who would benefit from immu...

Full description

Bibliographic Details
Main Authors:	Isidro Cortes-Ciriano, Sejoon Lee, Woong-Yang Park, Tae-Min Kim, Peter J. Park
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15180

id	doaj-b2b03e49a2a0482ab2a3e3eccf1875e9
record_format	Article
spelling	doaj-b2b03e49a2a0482ab2a3e3eccf1875e92021-05-11T07:21:45ZengNature Publishing GroupNature Communications2041-17232017-06-018111210.1038/ncomms15180A molecular portrait of microsatellite instability across multiple cancersIsidro Cortes-Ciriano0Sejoon Lee1Woong-Yang Park2Tae-Min Kim3Peter J. Park4Department of Biomedical Informatics, Harvard Medical SchoolSamsung Genome Institute, Samsung Medical CenterSamsung Genome Institute, Samsung Medical CenterDepartment of Medical Informatics and Catholic Cancer Research Institute, College of Medicine, The Catholic University of KoreaDepartment of Biomedical Informatics, Harvard Medical SchoolSome cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to identify patients who would benefit from immunotherapy.https://doi.org/10.1038/ncomms15180
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Isidro Cortes-Ciriano Sejoon Lee Woong-Yang Park Tae-Min Kim Peter J. Park
spellingShingle	Isidro Cortes-Ciriano Sejoon Lee Woong-Yang Park Tae-Min Kim Peter J. Park A molecular portrait of microsatellite instability across multiple cancers Nature Communications
author_facet	Isidro Cortes-Ciriano Sejoon Lee Woong-Yang Park Tae-Min Kim Peter J. Park
author_sort	Isidro Cortes-Ciriano
title	A molecular portrait of microsatellite instability across multiple cancers
title_short	A molecular portrait of microsatellite instability across multiple cancers
title_full	A molecular portrait of microsatellite instability across multiple cancers
title_fullStr	A molecular portrait of microsatellite instability across multiple cancers
title_full_unstemmed	A molecular portrait of microsatellite instability across multiple cancers
title_sort	molecular portrait of microsatellite instability across multiple cancers
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-06-01
description	Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to identify patients who would benefit from immunotherapy.
url	https://doi.org/10.1038/ncomms15180
work_keys_str_mv	AT isidrocortesciriano amolecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT sejoonlee amolecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT woongyangpark amolecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT taeminkim amolecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT peterjpark amolecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT isidrocortesciriano molecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT sejoonlee molecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT woongyangpark molecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT taeminkim molecularportraitofmicrosatelliteinstabilityacrossmultiplecancers AT peterjpark molecularportraitofmicrosatelliteinstabilityacrossmultiplecancers
_version_	1721452385542340608

A molecular portrait of microsatellite instability across multiple cancers

Similar Items