Association between maternal cannabis use and birth outcomes: an observational study
Abstract Background As cannabis consumption is increasing globally, including among pregnant women, there is a critical need to understand the effects of cannabis on fetal development and birth outcomes. We had two objectives: to determine 1) the factors associated with self-reported cannabis use in...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-12-01
|
Series: | BMC Pregnancy and Childbirth |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12884-020-03371-3 |
id |
doaj-b2b280c0e9de4c28b4b8de75924fd555 |
---|---|
record_format |
Article |
spelling |
doaj-b2b280c0e9de4c28b4b8de75924fd5552020-12-13T12:14:29ZengBMCBMC Pregnancy and Childbirth1471-23932020-12-012011910.1186/s12884-020-03371-3Association between maternal cannabis use and birth outcomes: an observational studyCamilla A. Michalski0Rayjean J. Hung1Ryan A. Seeto2Cindy-Lee Dennis3Jennifer D. Brooks4Joanna Henderson5Robert Levitan6Stephen J. Lye7Stephen G. Matthews8Julia A. Knight9Dalla Lana School of Public Health, University of TorontoDalla Lana School of Public Health, University of TorontoLunenfeld-Tanenbaum Research Institute, Sinai Health SystemLawrence S Bloomberg Faculty of Nursing, University of TorontoDalla Lana School of Public Health, University of TorontoCentre for Addiction and Mental HealthCentre for Addiction and Mental HealthLunenfeld-Tanenbaum Research Institute, Sinai Health SystemLunenfeld-Tanenbaum Research Institute, Sinai Health SystemDalla Lana School of Public Health, University of TorontoAbstract Background As cannabis consumption is increasing globally, including among pregnant women, there is a critical need to understand the effects of cannabis on fetal development and birth outcomes. We had two objectives: to determine 1) the factors associated with self-reported cannabis use in the pre/early-pregnancy period, and 2) whether cannabis use is associated with low birth weight, preterm birth, or small size for gestational age (GA) infants. Methods Maternal questionnaire and birth outcome data was gathered from 2229 women and 1778 singleton infants in the Ontario Birth Study, a hospital-based prospective cohort study (2013–2019). Women self-reported cannabis use within 3 months of learning their pregnancy status. Multivariable linear and logistic regression was conducted to 1) identify factors associated with cannabis use, and 2) determine the associations between cannabis use with the selected birth outcomes. Results Cannabis use increased in the cohort over time. Women who reported cannabis use (N = 216) were more likely to be younger and more likely to use alcohol, tobacco, and prescription pain medication, although most did not. These women had infants born at lower average birth weights and had 2.0 times the odds of being small for GA (95% confidence interval: 1.3, 3.3) after multivariable adjustment for socioeconomic factors and other substance use. Conclusion Our results suggest that women who use cannabis around the time of conception have higher odds of having infants that are small for gestational age. Targeted clinical messaging may be most applicable to women actively trying to conceive.https://doi.org/10.1186/s12884-020-03371-3CannabisMarijuanaEpidemiologyCanadaWomenPregnancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Camilla A. Michalski Rayjean J. Hung Ryan A. Seeto Cindy-Lee Dennis Jennifer D. Brooks Joanna Henderson Robert Levitan Stephen J. Lye Stephen G. Matthews Julia A. Knight |
spellingShingle |
Camilla A. Michalski Rayjean J. Hung Ryan A. Seeto Cindy-Lee Dennis Jennifer D. Brooks Joanna Henderson Robert Levitan Stephen J. Lye Stephen G. Matthews Julia A. Knight Association between maternal cannabis use and birth outcomes: an observational study BMC Pregnancy and Childbirth Cannabis Marijuana Epidemiology Canada Women Pregnancy |
author_facet |
Camilla A. Michalski Rayjean J. Hung Ryan A. Seeto Cindy-Lee Dennis Jennifer D. Brooks Joanna Henderson Robert Levitan Stephen J. Lye Stephen G. Matthews Julia A. Knight |
author_sort |
Camilla A. Michalski |
title |
Association between maternal cannabis use and birth outcomes: an observational study |
title_short |
Association between maternal cannabis use and birth outcomes: an observational study |
title_full |
Association between maternal cannabis use and birth outcomes: an observational study |
title_fullStr |
Association between maternal cannabis use and birth outcomes: an observational study |
title_full_unstemmed |
Association between maternal cannabis use and birth outcomes: an observational study |
title_sort |
association between maternal cannabis use and birth outcomes: an observational study |
publisher |
BMC |
series |
BMC Pregnancy and Childbirth |
issn |
1471-2393 |
publishDate |
2020-12-01 |
description |
Abstract Background As cannabis consumption is increasing globally, including among pregnant women, there is a critical need to understand the effects of cannabis on fetal development and birth outcomes. We had two objectives: to determine 1) the factors associated with self-reported cannabis use in the pre/early-pregnancy period, and 2) whether cannabis use is associated with low birth weight, preterm birth, or small size for gestational age (GA) infants. Methods Maternal questionnaire and birth outcome data was gathered from 2229 women and 1778 singleton infants in the Ontario Birth Study, a hospital-based prospective cohort study (2013–2019). Women self-reported cannabis use within 3 months of learning their pregnancy status. Multivariable linear and logistic regression was conducted to 1) identify factors associated with cannabis use, and 2) determine the associations between cannabis use with the selected birth outcomes. Results Cannabis use increased in the cohort over time. Women who reported cannabis use (N = 216) were more likely to be younger and more likely to use alcohol, tobacco, and prescription pain medication, although most did not. These women had infants born at lower average birth weights and had 2.0 times the odds of being small for GA (95% confidence interval: 1.3, 3.3) after multivariable adjustment for socioeconomic factors and other substance use. Conclusion Our results suggest that women who use cannabis around the time of conception have higher odds of having infants that are small for gestational age. Targeted clinical messaging may be most applicable to women actively trying to conceive. |
topic |
Cannabis Marijuana Epidemiology Canada Women Pregnancy |
url |
https://doi.org/10.1186/s12884-020-03371-3 |
work_keys_str_mv |
AT camillaamichalski associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT rayjeanjhung associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT ryanaseeto associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT cindyleedennis associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT jenniferdbrooks associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT joannahenderson associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT robertlevitan associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT stephenjlye associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT stephengmatthews associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy AT juliaaknight associationbetweenmaternalcannabisuseandbirthoutcomesanobservationalstudy |
_version_ |
1724385073660166144 |