Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC. METHODS:We retrospectively examined...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5242438?pdf=render |
id |
doaj-b2bfcbb2fc8b489fb909b30ba1f5691f |
---|---|
record_format |
Article |
spelling |
doaj-b2bfcbb2fc8b489fb909b30ba1f5691f2020-11-25T01:24:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01121e016786810.1371/journal.pone.0167868Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.Yan LiWei-Ya WangJiang-Hong XiaoFeng XuDian-Ying LiaoLi XieJin WangFeng LuoBACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC. METHODS:We retrospectively examined the paraffin-embedded tissue samples obtained from 54 patients with CRC who had received surgical therapies at our institution during 2006-2008. Rad51 expression in adenocarcinoma, paracancerous tissue, and normal colonic tissue was determined by immunohistochemistry. The correlation between Rad51 immunoreactivity and clinicopathologic features of these patients was evaluated. RESULTS:Rad51 immunoreactivity was detected in 67% of adenocarcinoma, 48% of paracancerous tissue, and 27% of normal colonic mucosa. Rad51 expression in adenocarcinoma was significantly higher than normal colonic tissue (p < 0.05). Rad51 was also overexpressed in poorly differentiated tumors and tumor samples from patients with lymph node metastasis (p < 0.05). Patients with Rad51 overexpression had a 69% two-year survival, 49% three-year survival, and 16% five-year survival, considerably worse than patients with negative Rad51 expression (p < 0.05). CONCLUSION:Our data suggest that Rad51 overexpression is correlated with malignant phenotypes of CRC and may predict poor prognosis for these patients.http://europepmc.org/articles/PMC5242438?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Li Wei-Ya Wang Jiang-Hong Xiao Feng Xu Dian-Ying Liao Li Xie Jin Wang Feng Luo |
spellingShingle |
Yan Li Wei-Ya Wang Jiang-Hong Xiao Feng Xu Dian-Ying Liao Li Xie Jin Wang Feng Luo Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. PLoS ONE |
author_facet |
Yan Li Wei-Ya Wang Jiang-Hong Xiao Feng Xu Dian-Ying Liao Li Xie Jin Wang Feng Luo |
author_sort |
Yan Li |
title |
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. |
title_short |
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. |
title_full |
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. |
title_fullStr |
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. |
title_full_unstemmed |
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. |
title_sort |
overexpression of rad51 predicts poor prognosis in colorectal cancer: our experience with 54 patients. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC. METHODS:We retrospectively examined the paraffin-embedded tissue samples obtained from 54 patients with CRC who had received surgical therapies at our institution during 2006-2008. Rad51 expression in adenocarcinoma, paracancerous tissue, and normal colonic tissue was determined by immunohistochemistry. The correlation between Rad51 immunoreactivity and clinicopathologic features of these patients was evaluated. RESULTS:Rad51 immunoreactivity was detected in 67% of adenocarcinoma, 48% of paracancerous tissue, and 27% of normal colonic mucosa. Rad51 expression in adenocarcinoma was significantly higher than normal colonic tissue (p < 0.05). Rad51 was also overexpressed in poorly differentiated tumors and tumor samples from patients with lymph node metastasis (p < 0.05). Patients with Rad51 overexpression had a 69% two-year survival, 49% three-year survival, and 16% five-year survival, considerably worse than patients with negative Rad51 expression (p < 0.05). CONCLUSION:Our data suggest that Rad51 overexpression is correlated with malignant phenotypes of CRC and may predict poor prognosis for these patients. |
url |
http://europepmc.org/articles/PMC5242438?pdf=render |
work_keys_str_mv |
AT yanli overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients AT weiyawang overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients AT jianghongxiao overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients AT fengxu overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients AT dianyingliao overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients AT lixie overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients AT jinwang overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients AT fengluo overexpressionofrad51predictspoorprognosisincolorectalcancerourexperiencewith54patients |
_version_ |
1725118073602572288 |