Numerical and experimental justification of transcatheter aortic valve prosthesis design
Objective: to justify the design of a self-expanding transcatheter aortic valve prosthesis based on a biomaterial stabilized with ethylene glycol diglycidyl ether using numerical simulation and a series of field experiments with working prototypes to determine the consistency of the proposed design...
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2021-07-01
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Online Access: | https://journal.transpl.ru/vtio/article/view/1200 |
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doaj-b2cc6e51faf94e2c82c39448ed53d72e2021-07-29T09:08:36ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov Vestnik Transplantologii i Iskusstvennyh Organov1995-11912021-07-012329510310.15825/1995-1191-2021-2-95-103975Numerical and experimental justification of transcatheter aortic valve prosthesis designE. A. Ovcharenko0K. U. Klyshnikov1A. A. Shilov2N. A. Scheglova3T. V. Glushkova4D. V. Nushtaev5L. S. Barbarash6Research Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesLOGEEKS Ltd.Research Institute for Complex Issues of Cardiovascular DiseasesSeverstal ManagementResearch Institute for Complex Issues of Cardiovascular DiseasesObjective: to justify the design of a self-expanding transcatheter aortic valve prosthesis based on a biomaterial stabilized with ethylene glycol diglycidyl ether using numerical simulation and a series of field experiments with working prototypes to determine the consistency of the proposed design solutions.Material and methods. Numerical computer models of a developed aortic valve prosthesis intended for transcatheter implantation, as well as prototypes of the most promising concepts for a series of field tests, were used in the work. Computer 3D models were subjected to numerical analysis in the Abaqus/CAE environment (Dassault Systemes, France) based on the finite element method with iterative design optimization and repeated numerical experiments. Physical prototypes of the transcatheter prosthesis were subjected to a series of mechanical tests for axial and radial compression, as well as tests on a Vivitro hydrodynamic stand (Vivitro Labs, Canada) under simulated normal flow. All studies were carried out in a comparative aspect with a similar transcatheter aortic valve prosthesis (control), the CoreValve™ bioprosthesis (Medtronic, Inc., USA).Results. Computer simulation demonstrates the stress-strain state values that do not significantly exceed the critical levels (628 and 756 MPa versus the threshold value 1080 MPa) for two basic concepts of support frames. The fatigue strength based on the calculation of the mean and alternating stresses corresponding to normo- and hypertensive states based on the Goodman diagrams, did not reveal any evidence that the threshold values (destruction area after 200 million cycles) were exceeded. The hydrodynamic characteristics of working prototypes made on the basis of computer models correspond to the testing data of CoreValve™ clinical bioprosthesis: the effective orifice area was 1.97 cm2, the mean transprosthetic gradient was 8.9 mm Hg, the regurgitant volume was 2.2–4.1 mL per cycle depending on the prototype model.Conclusion. Generally, experiments carried out showed the consistency of the concepts, including from the point of view of implementation of the leaflet apparatus based on xenogeneic tissues treated with ethylene glycol diglycidyl ether.https://journal.transpl.ru/vtio/article/view/1200transcatheter prosthesisaortic stenosisfinite element methodfluid dynamicsnumerical simulation |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E. A. Ovcharenko K. U. Klyshnikov A. A. Shilov N. A. Scheglova T. V. Glushkova D. V. Nushtaev L. S. Barbarash |
spellingShingle |
E. A. Ovcharenko K. U. Klyshnikov A. A. Shilov N. A. Scheglova T. V. Glushkova D. V. Nushtaev L. S. Barbarash Numerical and experimental justification of transcatheter aortic valve prosthesis design Vestnik Transplantologii i Iskusstvennyh Organov transcatheter prosthesis aortic stenosis finite element method fluid dynamics numerical simulation |
author_facet |
E. A. Ovcharenko K. U. Klyshnikov A. A. Shilov N. A. Scheglova T. V. Glushkova D. V. Nushtaev L. S. Barbarash |
author_sort |
E. A. Ovcharenko |
title |
Numerical and experimental justification of transcatheter aortic valve prosthesis design |
title_short |
Numerical and experimental justification of transcatheter aortic valve prosthesis design |
title_full |
Numerical and experimental justification of transcatheter aortic valve prosthesis design |
title_fullStr |
Numerical and experimental justification of transcatheter aortic valve prosthesis design |
title_full_unstemmed |
Numerical and experimental justification of transcatheter aortic valve prosthesis design |
title_sort |
numerical and experimental justification of transcatheter aortic valve prosthesis design |
publisher |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
series |
Vestnik Transplantologii i Iskusstvennyh Organov |
issn |
1995-1191 |
publishDate |
2021-07-01 |
description |
Objective: to justify the design of a self-expanding transcatheter aortic valve prosthesis based on a biomaterial stabilized with ethylene glycol diglycidyl ether using numerical simulation and a series of field experiments with working prototypes to determine the consistency of the proposed design solutions.Material and methods. Numerical computer models of a developed aortic valve prosthesis intended for transcatheter implantation, as well as prototypes of the most promising concepts for a series of field tests, were used in the work. Computer 3D models were subjected to numerical analysis in the Abaqus/CAE environment (Dassault Systemes, France) based on the finite element method with iterative design optimization and repeated numerical experiments. Physical prototypes of the transcatheter prosthesis were subjected to a series of mechanical tests for axial and radial compression, as well as tests on a Vivitro hydrodynamic stand (Vivitro Labs, Canada) under simulated normal flow. All studies were carried out in a comparative aspect with a similar transcatheter aortic valve prosthesis (control), the CoreValve™ bioprosthesis (Medtronic, Inc., USA).Results. Computer simulation demonstrates the stress-strain state values that do not significantly exceed the critical levels (628 and 756 MPa versus the threshold value 1080 MPa) for two basic concepts of support frames. The fatigue strength based on the calculation of the mean and alternating stresses corresponding to normo- and hypertensive states based on the Goodman diagrams, did not reveal any evidence that the threshold values (destruction area after 200 million cycles) were exceeded. The hydrodynamic characteristics of working prototypes made on the basis of computer models correspond to the testing data of CoreValve™ clinical bioprosthesis: the effective orifice area was 1.97 cm2, the mean transprosthetic gradient was 8.9 mm Hg, the regurgitant volume was 2.2–4.1 mL per cycle depending on the prototype model.Conclusion. Generally, experiments carried out showed the consistency of the concepts, including from the point of view of implementation of the leaflet apparatus based on xenogeneic tissues treated with ethylene glycol diglycidyl ether. |
topic |
transcatheter prosthesis aortic stenosis finite element method fluid dynamics numerical simulation |
url |
https://journal.transpl.ru/vtio/article/view/1200 |
work_keys_str_mv |
AT eaovcharenko numericalandexperimentaljustificationoftranscatheteraorticvalveprosthesisdesign AT kuklyshnikov numericalandexperimentaljustificationoftranscatheteraorticvalveprosthesisdesign AT aashilov numericalandexperimentaljustificationoftranscatheteraorticvalveprosthesisdesign AT nascheglova numericalandexperimentaljustificationoftranscatheteraorticvalveprosthesisdesign AT tvglushkova numericalandexperimentaljustificationoftranscatheteraorticvalveprosthesisdesign AT dvnushtaev numericalandexperimentaljustificationoftranscatheteraorticvalveprosthesisdesign AT lsbarbarash numericalandexperimentaljustificationoftranscatheteraorticvalveprosthesisdesign |
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