Development of Eosinophilia in dogs intradermically inoculated with sand fly saliva and Leishmania (Leishmania) chagasi stationary-phase promastigotes

• Main Authors: Moacir Paranhos, Washington C. dos Santos, Italo Sherlock, Geraldo G. S. Oliveira, Lain C. Pontes de Carvalho
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1993-06-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Leishmania chagasi; Lutzomia longipalpis; sand fly saliva; eosinophilia; infectivity; experimental infection; dogs
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200012
• ISSN: 0074-0276; 1678-8060

Salivary glad lysates of the sand fly Lutzomia longipalpis have been shown to enhance the infectivity of Leishmania in mice. As shown herein, the simultaneous inoculation of Leishmania chagasi stationary-phase promastigotes and L. longipalpis salivary gland by the intradermal route in a group of mongrel dogs induced a statistically significant eosinophilia, in relation to dogs inoculated with Leishmania or with salivary gland lysate only. These dogs had no evidence of infection, in spite of the infectivity of the promastigotes when inoculated by the intravenous route.