In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis cases
Objective: The increase in resistance to gram positive organisms and seriousness of infective endocarditis, makes it necessary to look for an alternate treatment. Methods: In-vitro activity of synercid was compared with penicillin, amoxycillin, teicoplanin, vancomycin, clindamycin and erythromycin....
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doaj-b2e0b504eda94bbeab2e2d0fc1b25ec42020-11-25T03:25:47ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal 2075-051X2075-05282000-01-012125311119In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis casesRafay A M0Department of Microbiology, College of Medicine, Sultan Qaboos University, P.O.Box: 35, Postal Code: 123, Muscat, Sultanate of OmanObjective: The increase in resistance to gram positive organisms and seriousness of infective endocarditis, makes it necessary to look for an alternate treatment. Methods: In-vitro activity of synercid was compared with penicillin, amoxycillin, teicoplanin, vancomycin, clindamycin and erythromycin. Results: Synercid showed minimum inhibitory concentrations (MIC) within the narrow range of 0.06 – 0.5 mg/l. MIC50 and mode values were both 0.25 mg/l. There was just two-fold difference between the MIC50 (0.25 mg/l) and the MIC90, (0.5 mg/l). Although the MICs of synercid for S. oralis were relatively high compared to penicillin, clindamycin, erythromycin and teicoplanin, the in-vitro bactericidal activity of synercid was much greater. Synercid MBC values were < 4 mg/l for most of the isolates, except for one of 16 mg/l and the other >64 mg/l. Killing curve was performed on six isolates of S. oralis from infective endocarditis, two from septicaemia patients and two from the oral flora of normal individuals. Conclusion: Synercid showed superior bactericidal activity when compared to penicillin and vancomycin against all ten isolates of S. oralis tested. Synercid was bactericidal (99.9% kill) against all ten isolates of S. oralis within six hours of contact.https://journals.squ.edu.om/index.php/squmj/article/view/1190streptococcus oralis, synercid, penicillin, amoxycillin, erythromycin, vancomycin, teicoplanin, clindamycin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rafay A M |
spellingShingle |
Rafay A M In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis cases Sultan Qaboos University Medical Journal streptococcus oralis, synercid, penicillin, amoxycillin, erythromycin, vancomycin, teicoplanin, clindamycin |
author_facet |
Rafay A M |
author_sort |
Rafay A M |
title |
In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis cases |
title_short |
In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis cases |
title_full |
In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis cases |
title_fullStr |
In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis cases |
title_full_unstemmed |
In-vitro Activity of Synercid and related Drugs against Streptococcus Oralis Isolated from Septicaemia and Endocarditis cases |
title_sort |
in-vitro activity of synercid and related drugs against streptococcus oralis isolated from septicaemia and endocarditis cases |
publisher |
Sultan Qaboos University |
series |
Sultan Qaboos University Medical Journal |
issn |
2075-051X 2075-0528 |
publishDate |
2000-01-01 |
description |
Objective: The increase in resistance to gram positive organisms and seriousness of infective endocarditis, makes it necessary to look for an alternate treatment. Methods: In-vitro activity of synercid was compared with penicillin, amoxycillin, teicoplanin, vancomycin, clindamycin and erythromycin. Results: Synercid showed minimum inhibitory concentrations (MIC) within the narrow range of 0.06 – 0.5 mg/l. MIC50 and mode values were both 0.25 mg/l. There was just two-fold difference between the MIC50 (0.25 mg/l) and the MIC90, (0.5 mg/l). Although the MICs of synercid for S. oralis were relatively high compared to penicillin, clindamycin, erythromycin and teicoplanin, the in-vitro bactericidal activity of synercid was much greater. Synercid MBC values were < 4 mg/l for most of the isolates, except for one of 16 mg/l and the other >64 mg/l. Killing curve was performed on six isolates of S. oralis from infective endocarditis, two from septicaemia patients and two from the oral flora of normal individuals. Conclusion: Synercid showed superior bactericidal activity when compared to penicillin and vancomycin against all ten isolates of S. oralis tested. Synercid was bactericidal (99.9% kill) against all ten isolates of S. oralis within six hours of contact. |
topic |
streptococcus oralis, synercid, penicillin, amoxycillin, erythromycin, vancomycin, teicoplanin, clindamycin |
url |
https://journals.squ.edu.om/index.php/squmj/article/view/1190 |
work_keys_str_mv |
AT rafayam invitroactivityofsynercidandrelateddrugsagainststreptococcusoralisisolatedfromsepticaemiaandendocarditiscases |
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