Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes

Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes

Abstract Background Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous (LGSOC), endometrioid (ENOC), clear cell (CCOC) and mucinous (MOC). Although HGSOC is the most prevalent subtype, repres...

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Bibliographic Details
Main Authors: Bethany M. Barnes, Louisa Nelson, Anthony Tighe, George J. Burghel, I-Hsuan Lin, Sudha Desai, Joanne C. McGrail, Robert D. Morgan, Stephen S. Taylor
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Medicine
Subjects:
Ovarian cancer
Non-negative matrix factorization
RNA sequencing
Subtype classification
Machine learning
Transcriptomics
Online Access:https://doi.org/10.1186/s13073-021-00952-5

Internet

https://doi.org/10.1186/s13073-021-00952-5

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