Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer

Abstract Background Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) is a standard method for pathological diagnosis of pancreatic solid lesions. The EchoTip ProCore 20G® (PC20), a 20-gauge biopsy needle with a forward-bevel core trap, has been available in Japan since 2015. Me...

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Main Authors: Shunsuke Watanabe, Jun Miyoshi, Masao Toki, Komei Kambayashi, Shuichi Kitada, Takeshi Nosaka, Tomoyuki Goto, Hirotaka Ota, Kazushige Ochiai, Koichi Gondo, Nobuhito Ikeuchi, Shujiro Tsuji, Kenji Nakamura, Junji Shibahara, Tadakazu Hisamatsu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Gastroenterology
Subjects:
Online Access:https://doi.org/10.1186/s12876-020-01583-7
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spelling doaj-b2fcf6fc059140f8aa324f94424a73952021-01-10T12:28:39ZengBMCBMC Gastroenterology1471-230X2021-01-012111810.1186/s12876-020-01583-7Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancerShunsuke Watanabe0Jun Miyoshi1Masao Toki2Komei Kambayashi3Shuichi Kitada4Takeshi Nosaka5Tomoyuki Goto6Hirotaka Ota7Kazushige Ochiai8Koichi Gondo9Nobuhito Ikeuchi10Shujiro Tsuji11Kenji Nakamura12Junji Shibahara13Tadakazu Hisamatsu14Department of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Tokyo Medical UniversityDepartment of Gastroenterology and Hepatology, Tokyo Medical UniversityDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineDepartment of Pathology, Kyorin University School of MedicineDepartment of Gastroenterology and Hepatology, Kyorin University School of MedicineAbstract Background Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) is a standard method for pathological diagnosis of pancreatic solid lesions. The EchoTip ProCore 20G® (PC20), a 20-gauge biopsy needle with a forward-bevel core trap, has been available in Japan since 2015. Methods We compared the efficacy of the PC20 with that of the EchoTip ProCore 22G® (PC22) and Acquire 22G® (AC22) in EUS-FNA/B for diagnosing pancreatic cancer. This retrospective study included 191 patients with pancreatic cancer who underwent EUS-FNA/B using the PC20, PC22, or AC22 at our facility from April 2013 to October 2019. We investigated the patients’ clinical characteristics and the diagnostic accuracy and safety of each needle. Results A sufficient stroke length of puncture was secured in all patients. The maximum length under EUS was shorter with the AC22 (22.1 ± 2.2 mm) than PC20 (30.6 ± 0.7 mm, p < 0.01) and PC22 (30.3 ± 0.8 mm, p < 0.01). The histological accuracy was 96.4% with the PC20 but only 58.8% with the PC22 (adjusted p (p-adj) < 0.0001) and 75.0% with the AC22 (p-adj = 0.06). The diagnostic accuracy of the combination of histology and cytology was 96.4% with the PC20, while it was 72.1% with the PC22 (p-adj < 0.0001) and 91.7% with the AC22 (p-adj > 0.99). One patient (0.9%) in the PC20 group developed mild pancreatitis, but no adverse events occurred with the other needles. Conclusions The PC20 showed better diagnostic capability than the PC22. The diagnostic efficacy was similar between the PC20 and AC22. The high histological accuracy of the PC20 could be advantageous for lesions in which histological assessment is critical.https://doi.org/10.1186/s12876-020-01583-7Pancreatic cancerEndoscopic ultrasound-guided fine needle aspiration/biopsyProCore 20-gauge needleDiagnostic accuracy
collection DOAJ
language English
format Article
sources DOAJ
author Shunsuke Watanabe
Jun Miyoshi
Masao Toki
Komei Kambayashi
Shuichi Kitada
Takeshi Nosaka
Tomoyuki Goto
Hirotaka Ota
Kazushige Ochiai
Koichi Gondo
Nobuhito Ikeuchi
Shujiro Tsuji
Kenji Nakamura
Junji Shibahara
Tadakazu Hisamatsu
spellingShingle Shunsuke Watanabe
Jun Miyoshi
Masao Toki
Komei Kambayashi
Shuichi Kitada
Takeshi Nosaka
Tomoyuki Goto
Hirotaka Ota
Kazushige Ochiai
Koichi Gondo
Nobuhito Ikeuchi
Shujiro Tsuji
Kenji Nakamura
Junji Shibahara
Tadakazu Hisamatsu
Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer
BMC Gastroenterology
Pancreatic cancer
Endoscopic ultrasound-guided fine needle aspiration/biopsy
ProCore 20-gauge needle
Diagnostic accuracy
author_facet Shunsuke Watanabe
Jun Miyoshi
Masao Toki
Komei Kambayashi
Shuichi Kitada
Takeshi Nosaka
Tomoyuki Goto
Hirotaka Ota
Kazushige Ochiai
Koichi Gondo
Nobuhito Ikeuchi
Shujiro Tsuji
Kenji Nakamura
Junji Shibahara
Tadakazu Hisamatsu
author_sort Shunsuke Watanabe
title Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer
title_short Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer
title_full Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer
title_fullStr Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer
title_full_unstemmed Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer
title_sort effectiveness of introducing a 20-gauge core biopsy needle with a core trap in eus-fna/b for diagnosing pancreatic cancer
publisher BMC
series BMC Gastroenterology
issn 1471-230X
publishDate 2021-01-01
description Abstract Background Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) is a standard method for pathological diagnosis of pancreatic solid lesions. The EchoTip ProCore 20G® (PC20), a 20-gauge biopsy needle with a forward-bevel core trap, has been available in Japan since 2015. Methods We compared the efficacy of the PC20 with that of the EchoTip ProCore 22G® (PC22) and Acquire 22G® (AC22) in EUS-FNA/B for diagnosing pancreatic cancer. This retrospective study included 191 patients with pancreatic cancer who underwent EUS-FNA/B using the PC20, PC22, or AC22 at our facility from April 2013 to October 2019. We investigated the patients’ clinical characteristics and the diagnostic accuracy and safety of each needle. Results A sufficient stroke length of puncture was secured in all patients. The maximum length under EUS was shorter with the AC22 (22.1 ± 2.2 mm) than PC20 (30.6 ± 0.7 mm, p < 0.01) and PC22 (30.3 ± 0.8 mm, p < 0.01). The histological accuracy was 96.4% with the PC20 but only 58.8% with the PC22 (adjusted p (p-adj) < 0.0001) and 75.0% with the AC22 (p-adj = 0.06). The diagnostic accuracy of the combination of histology and cytology was 96.4% with the PC20, while it was 72.1% with the PC22 (p-adj < 0.0001) and 91.7% with the AC22 (p-adj > 0.99). One patient (0.9%) in the PC20 group developed mild pancreatitis, but no adverse events occurred with the other needles. Conclusions The PC20 showed better diagnostic capability than the PC22. The diagnostic efficacy was similar between the PC20 and AC22. The high histological accuracy of the PC20 could be advantageous for lesions in which histological assessment is critical.
topic Pancreatic cancer
Endoscopic ultrasound-guided fine needle aspiration/biopsy
ProCore 20-gauge needle
Diagnostic accuracy
url https://doi.org/10.1186/s12876-020-01583-7
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