Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity
Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure. Whether those nanoparticles are generated through intentional or unintentional means,...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
KeAi Communications Co., Ltd.
2021-09-01
|
Series: | Bioactive Materials |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21000335 |
id |
doaj-b320f039149e46ad931c6532000acfe8 |
---|---|
record_format |
Article |
spelling |
doaj-b320f039149e46ad931c6532000acfe82021-06-17T04:48:16ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-09-016928012819Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicityRick Xing Ze Lu0Milica Radisic1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CanadaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada; Toronto General Research Institute, University Health Network, Toronto, ON, Canada; The Heart and Stroke/Richard Lewar Centre of Excellence, Toronto, ON, Canada; Corresponding author.Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure. Whether those nanoparticles are generated through intentional or unintentional means, the constant exposure to nanomaterials can inevitably lead to unintended consequences based on epidemiological data, yet the current understanding of nanotoxicity is insufficient relative to the rate of their emission in the environment and the lack of predictive platforms that mimic the human physiology. This calls for a development of more physiologically relevant models, which permit the comprehensive and systematic examination of toxic properties of nanoparticles. With the advancement in microfabrication techniques, scientists have shifted their focus on the development of an engineered system that acts as an intermediate between a well-plate system and animal models, known as organ-on-a-chips. The ability of organ-on-a-chip models to recapitulate in vivo like microenvironment and responses offers a new avenue for nanotoxicological research. In this review, we aim to provide overview of assessing potential risks of nanoparticle exposure using organ-on-a-chip systems and their potential to delineate biological mechanisms of epidemiological findings.http://www.sciencedirect.com/science/article/pii/S2452199X21000335Organ-on-a-chipToxicityNanoparticles |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rick Xing Ze Lu Milica Radisic |
spellingShingle |
Rick Xing Ze Lu Milica Radisic Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity Bioactive Materials Organ-on-a-chip Toxicity Nanoparticles |
author_facet |
Rick Xing Ze Lu Milica Radisic |
author_sort |
Rick Xing Ze Lu |
title |
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity |
title_short |
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity |
title_full |
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity |
title_fullStr |
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity |
title_full_unstemmed |
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity |
title_sort |
organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2021-09-01 |
description |
Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure. Whether those nanoparticles are generated through intentional or unintentional means, the constant exposure to nanomaterials can inevitably lead to unintended consequences based on epidemiological data, yet the current understanding of nanotoxicity is insufficient relative to the rate of their emission in the environment and the lack of predictive platforms that mimic the human physiology. This calls for a development of more physiologically relevant models, which permit the comprehensive and systematic examination of toxic properties of nanoparticles. With the advancement in microfabrication techniques, scientists have shifted their focus on the development of an engineered system that acts as an intermediate between a well-plate system and animal models, known as organ-on-a-chips. The ability of organ-on-a-chip models to recapitulate in vivo like microenvironment and responses offers a new avenue for nanotoxicological research. In this review, we aim to provide overview of assessing potential risks of nanoparticle exposure using organ-on-a-chip systems and their potential to delineate biological mechanisms of epidemiological findings. |
topic |
Organ-on-a-chip Toxicity Nanoparticles |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X21000335 |
work_keys_str_mv |
AT rickxingzelu organonachipplatformsforevaluationofenvironmentalnanoparticletoxicity AT milicaradisic organonachipplatformsforevaluationofenvironmentalnanoparticletoxicity |
_version_ |
1721374441974267904 |