Mesenchymal stem cells derived from human induced pluripotent stem cells improve the engraftment of myogenic cells by secreting urokinase-type plasminogen activator receptor (uPAR)

Mesenchymal stem cells derived from human induced pluripotent stem cells improve the engraftment of myogenic cells by secreting urokinase-type plasminogen activator receptor (uPAR)

Abstract Background Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disease caused by mutations in the dystrophin gene. Transplantation of myogenic stem cells holds great promise for treating muscular dystrophies. However, poor engraftment of myogenic stem cells limits the therapeut...

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Bibliographic Details
Main Authors: Ahmed Elhussieny, Ken’ichiro Nogami, Fusako Sakai-Takemura, Yusuke Maruyama, Natsumi Takemura, Wael Talaat Soliman, Shin’ichi Takeda, Yuko Miyagoe-Suzuki
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Stem Cell Research & Therapy
Subjects:
Human iPS cells
Mesenchymal stem cells
Skeletal muscle
Muscle progenitors
Cell transplantation
Duchenne muscular dystrophy (DMD)
Online Access:https://doi.org/10.1186/s13287-021-02594-1

Internet

https://doi.org/10.1186/s13287-021-02594-1

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