Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol

The aim of this research was to increase sum of total rat’s leucocytes and macrophages using Coriolus versicolor exposure2-Methoxythanol (2-ME). Coriolus versicolor extract have been primary active compounds are polysaccharide krestin (PSK). Thiscompound PSK contains of ß-glucan. The immune cells...

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Main Author: Sri Puji Astuti Wahyuningsih
Format: Article
Language:English
Published: Indonesian Biological Society 2012-02-01
Series:Journal of Biological Researches
Subjects:
Online Access:http://berkalahayati.org/journal/19d385eb
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spelling doaj-b33cfbded201423e9dc8472c3a30d01c2020-11-24T23:34:09ZengIndonesian Biological SocietyJournal of Biological Researches0852-68342337-389X2012-02-0113217317710.23869/bphjbr.13.2.200812Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanolSri Puji Astuti Wahyuningsih0Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas AirlanggaThe aim of this research was to increase sum of total rat’s leucocytes and macrophages using Coriolus versicolor exposure2-Methoxythanol (2-ME). Coriolus versicolor extract have been primary active compounds are polysaccharide krestin (PSK). Thiscompound PSK contains of ß-glucan. The immune cells had b-glucan receptor. From this reason, Coriolus versicolor extract couldincrease of immune system after exposed 2-ME. This research used 30 of 3–4 month female rats, and they were divided into 5 groups.K (control), P1 (exposed by 2-ME), P2 (administered with Coriolus versicolor extract before exposed by 2-ME), P3 (administered withCoriolus versicolor extract after exposed by 2-ME), P4 (administered with Coriolus versicolor extract before and after exposed by2-ME). Coriolus versicolor extract used dose of 300 mg/kg body weight was given with gavage. 2-ME dose of 11 mmol/kg body weightwas given with injection at cavum peritoneum. Number on leucocytes and macrophages counted by using Haemocytometer ImprovedNeubauer. The data was analyzed with ANOVA, further more if any differences were analyzed with LSD. Result of this study showed that(1) P1 decreased on the total number of leucocytes if compared with K, but increased on the total number of macrophage.(2) P2, P3, and P4 increased the total number of leucocytes and macrophage. Suggestion that can be proposed from thisresearch was Coriolus versicolor extract can repair and increase immune system. http://berkalahayati.org/journal/19d385ebCoriolus versicolor2-methoxyethanolleucocytesmacrophage
collection DOAJ
language English
format Article
sources DOAJ
author Sri Puji Astuti Wahyuningsih
spellingShingle Sri Puji Astuti Wahyuningsih
Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol
Journal of Biological Researches
Coriolus versicolor
2-methoxyethanol
leucocytes
macrophage
author_facet Sri Puji Astuti Wahyuningsih
author_sort Sri Puji Astuti Wahyuningsih
title Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol
title_short Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol
title_full Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol
title_fullStr Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol
title_full_unstemmed Pemanfaatan ekstrak jamur Coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol
title_sort pemanfaatan ekstrak jamur coriolus versicolor untuk meningkatkan jumlah total leukosit dan makrofag pada tikus putih wistar setelah pemaparan 2-methoxyethanol
publisher Indonesian Biological Society
series Journal of Biological Researches
issn 0852-6834
2337-389X
publishDate 2012-02-01
description The aim of this research was to increase sum of total rat’s leucocytes and macrophages using Coriolus versicolor exposure2-Methoxythanol (2-ME). Coriolus versicolor extract have been primary active compounds are polysaccharide krestin (PSK). Thiscompound PSK contains of ß-glucan. The immune cells had b-glucan receptor. From this reason, Coriolus versicolor extract couldincrease of immune system after exposed 2-ME. This research used 30 of 3–4 month female rats, and they were divided into 5 groups.K (control), P1 (exposed by 2-ME), P2 (administered with Coriolus versicolor extract before exposed by 2-ME), P3 (administered withCoriolus versicolor extract after exposed by 2-ME), P4 (administered with Coriolus versicolor extract before and after exposed by2-ME). Coriolus versicolor extract used dose of 300 mg/kg body weight was given with gavage. 2-ME dose of 11 mmol/kg body weightwas given with injection at cavum peritoneum. Number on leucocytes and macrophages counted by using Haemocytometer ImprovedNeubauer. The data was analyzed with ANOVA, further more if any differences were analyzed with LSD. Result of this study showed that(1) P1 decreased on the total number of leucocytes if compared with K, but increased on the total number of macrophage.(2) P2, P3, and P4 increased the total number of leucocytes and macrophage. Suggestion that can be proposed from thisresearch was Coriolus versicolor extract can repair and increase immune system.
topic Coriolus versicolor
2-methoxyethanol
leucocytes
macrophage
url http://berkalahayati.org/journal/19d385eb
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