Understanding Platelets in Infectious and Allergic Lung Diseases
Emerging evidence suggests that platelets, cytoplasmic fragments derived from megakaryocytes, can no longer be considered just as mediators in hemostasis and coagulation processes, but as key modulators of immunity. Platelets have received increasing attention as the emergence of new methodologies h...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-04-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/7/1730 |
id |
doaj-b34113d79ad34f3fa162d09990c638e8 |
---|---|
record_format |
Article |
spelling |
doaj-b34113d79ad34f3fa162d09990c638e82020-11-25T01:14:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-04-01207173010.3390/ijms20071730ijms20071730Understanding Platelets in Infectious and Allergic Lung DiseasesCristina Gomez-Casado0Alma Villaseñor1Alba Rodriguez-Nogales2Jose Luis Bueno3Domingo Barber4Maria M. Escribese5Institute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of Medicine, San Pablo CEU University, 28668 Madrid, SpainInstitute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of Medicine, San Pablo CEU University, 28668 Madrid, SpainResearch Laboratory, Allergy Unit, University Hospital of Malaga-IBIMA, 29010 Malaga, SpainBlood Transfusion & Non-Transfusional Hemotherapy Unit, University Hospital Puerta de Hierro-Majadahonda, 28220 Madrid, SpainInstitute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of Medicine, San Pablo CEU University, 28668 Madrid, SpainInstitute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of Medicine, San Pablo CEU University, 28668 Madrid, SpainEmerging evidence suggests that platelets, cytoplasmic fragments derived from megakaryocytes, can no longer be considered just as mediators in hemostasis and coagulation processes, but as key modulators of immunity. Platelets have received increasing attention as the emergence of new methodologies has allowed the characterization of their components and functions in the immune continuum. Platelet activation in infectious and allergic lung diseases has been well documented and associated with bacterial infections reproduced in several animal models of pulmonary bacterial infections. Direct interactions between platelets and bacteria have been associated with increased pulmonary platelet accumulation, whereas bacterial-derived toxins have also been reported to modulate platelet function. Recently, platelets have been found extravascular in the lungs of patients with asthma, and in animal models of allergic lung inflammation. Their ability to interact with immune and endothelial cells and secrete immune mediators makes them one attractive target for biomarker identification that will help characterize their contribution to lung diseases. Here, we present an original review of the last advances in the platelet field with a focus on the contribution of platelets to respiratory infections and allergic-mediated diseases.https://www.mdpi.com/1422-0067/20/7/1730plateletsmediatorsallergic inflammationinfectious disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cristina Gomez-Casado Alma Villaseñor Alba Rodriguez-Nogales Jose Luis Bueno Domingo Barber Maria M. Escribese |
spellingShingle |
Cristina Gomez-Casado Alma Villaseñor Alba Rodriguez-Nogales Jose Luis Bueno Domingo Barber Maria M. Escribese Understanding Platelets in Infectious and Allergic Lung Diseases International Journal of Molecular Sciences platelets mediators allergic inflammation infectious disease |
author_facet |
Cristina Gomez-Casado Alma Villaseñor Alba Rodriguez-Nogales Jose Luis Bueno Domingo Barber Maria M. Escribese |
author_sort |
Cristina Gomez-Casado |
title |
Understanding Platelets in Infectious and Allergic Lung Diseases |
title_short |
Understanding Platelets in Infectious and Allergic Lung Diseases |
title_full |
Understanding Platelets in Infectious and Allergic Lung Diseases |
title_fullStr |
Understanding Platelets in Infectious and Allergic Lung Diseases |
title_full_unstemmed |
Understanding Platelets in Infectious and Allergic Lung Diseases |
title_sort |
understanding platelets in infectious and allergic lung diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-04-01 |
description |
Emerging evidence suggests that platelets, cytoplasmic fragments derived from megakaryocytes, can no longer be considered just as mediators in hemostasis and coagulation processes, but as key modulators of immunity. Platelets have received increasing attention as the emergence of new methodologies has allowed the characterization of their components and functions in the immune continuum. Platelet activation in infectious and allergic lung diseases has been well documented and associated with bacterial infections reproduced in several animal models of pulmonary bacterial infections. Direct interactions between platelets and bacteria have been associated with increased pulmonary platelet accumulation, whereas bacterial-derived toxins have also been reported to modulate platelet function. Recently, platelets have been found extravascular in the lungs of patients with asthma, and in animal models of allergic lung inflammation. Their ability to interact with immune and endothelial cells and secrete immune mediators makes them one attractive target for biomarker identification that will help characterize their contribution to lung diseases. Here, we present an original review of the last advances in the platelet field with a focus on the contribution of platelets to respiratory infections and allergic-mediated diseases. |
topic |
platelets mediators allergic inflammation infectious disease |
url |
https://www.mdpi.com/1422-0067/20/7/1730 |
work_keys_str_mv |
AT cristinagomezcasado understandingplateletsininfectiousandallergiclungdiseases AT almavillasenor understandingplateletsininfectiousandallergiclungdiseases AT albarodrigueznogales understandingplateletsininfectiousandallergiclungdiseases AT joseluisbueno understandingplateletsininfectiousandallergiclungdiseases AT domingobarber understandingplateletsininfectiousandallergiclungdiseases AT mariamescribese understandingplateletsininfectiousandallergiclungdiseases |
_version_ |
1725155790276263936 |