Regulation of triglyceride metabolism by glucocorticoid receptor
<p>Abstract</p> <p>Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis and hydrolysis. More intriguingly, glucocorticoids can...
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doaj-b349c8582d864851a8bf9cc7df8b8a492020-11-25T00:23:34ZengBMCCell & Bioscience2045-37012012-05-01211910.1186/2045-3701-2-19Regulation of triglyceride metabolism by glucocorticoid receptorWang Jen-ChywanGray Nora EKuo TaiyiHarris Charles A<p>Abstract</p> <p>Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis and hydrolysis. More intriguingly, glucocorticoids can concurrently affect these two processes in adipocytes. The metabolic effects of glucocorticoids are conferred by intracellular glucocorticoid receptors (GR). GR is a transcription factor that, upon binding to glucocorticoids, regulates the transcriptional rate of specific genes. These GR primary target genes further initiate the physiological and pathological responses of glucocorticoids. In this article, we overview glucocorticoid-regulated genes, especially those potential GR primary target genes, involved in glucocorticoid-regulated TG metabolism. We also discuss transcriptional regulators that could act with GR to participate in these processes. This knowledge is not only important for the fundamental understanding of steroid hormone actions, but also are essential for future therapeutic interventions against metabolic diseases associated with aberrant glucocorticoid signaling, such as insulin resistance, dyslipidemia, central obesity and hepatic steatosis.</p> http://www.cellandbioscience.com/content/2/1/19GlucocorticoidGlucocorticoid receptorTriglycerideLipogenesisLipolysisGlucocorticoid response ElementTranscription |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wang Jen-Chywan Gray Nora E Kuo Taiyi Harris Charles A |
spellingShingle |
Wang Jen-Chywan Gray Nora E Kuo Taiyi Harris Charles A Regulation of triglyceride metabolism by glucocorticoid receptor Cell & Bioscience Glucocorticoid Glucocorticoid receptor Triglyceride Lipogenesis Lipolysis Glucocorticoid response Element Transcription |
author_facet |
Wang Jen-Chywan Gray Nora E Kuo Taiyi Harris Charles A |
author_sort |
Wang Jen-Chywan |
title |
Regulation of triglyceride metabolism by glucocorticoid receptor |
title_short |
Regulation of triglyceride metabolism by glucocorticoid receptor |
title_full |
Regulation of triglyceride metabolism by glucocorticoid receptor |
title_fullStr |
Regulation of triglyceride metabolism by glucocorticoid receptor |
title_full_unstemmed |
Regulation of triglyceride metabolism by glucocorticoid receptor |
title_sort |
regulation of triglyceride metabolism by glucocorticoid receptor |
publisher |
BMC |
series |
Cell & Bioscience |
issn |
2045-3701 |
publishDate |
2012-05-01 |
description |
<p>Abstract</p> <p>Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis and hydrolysis. More intriguingly, glucocorticoids can concurrently affect these two processes in adipocytes. The metabolic effects of glucocorticoids are conferred by intracellular glucocorticoid receptors (GR). GR is a transcription factor that, upon binding to glucocorticoids, regulates the transcriptional rate of specific genes. These GR primary target genes further initiate the physiological and pathological responses of glucocorticoids. In this article, we overview glucocorticoid-regulated genes, especially those potential GR primary target genes, involved in glucocorticoid-regulated TG metabolism. We also discuss transcriptional regulators that could act with GR to participate in these processes. This knowledge is not only important for the fundamental understanding of steroid hormone actions, but also are essential for future therapeutic interventions against metabolic diseases associated with aberrant glucocorticoid signaling, such as insulin resistance, dyslipidemia, central obesity and hepatic steatosis.</p> |
topic |
Glucocorticoid Glucocorticoid receptor Triglyceride Lipogenesis Lipolysis Glucocorticoid response Element Transcription |
url |
http://www.cellandbioscience.com/content/2/1/19 |
work_keys_str_mv |
AT wangjenchywan regulationoftriglyceridemetabolismbyglucocorticoidreceptor AT graynorae regulationoftriglyceridemetabolismbyglucocorticoidreceptor AT kuotaiyi regulationoftriglyceridemetabolismbyglucocorticoidreceptor AT harrischarlesa regulationoftriglyceridemetabolismbyglucocorticoidreceptor |
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1725356341833236480 |