Effects of carbophos on rat testopathy following resveratrol administration: An experimental study
Objective: Carbophos (CAR) is an organophosphate that is most capable of producing free radicals and inducing alteration in some of the male reproductive parameters. Resveratrol (RES) is an herbal polyphenol and exerts beneficial antioxidant effects. This study aimed to evaluate the effects of RES a...
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doaj-b3520b75d2af4b178c3c48e2931cc59c2020-11-25T02:36:24ZengWolters Kluwer Medknow PublicationsReproductive and Developmental Medicine2096-29242589-87282019-01-013422222910.4103/2096-2924.274545Effects of carbophos on rat testopathy following resveratrol administration: An experimental studyCyrus JaliliShiva RoshankhahAzita FaramarziMohammad Reza SalahshoorObjective: Carbophos (CAR) is an organophosphate that is most capable of producing free radicals and inducing alteration in some of the male reproductive parameters. Resveratrol (RES) is an herbal polyphenol and exerts beneficial antioxidant effects. This study aimed to evaluate the effects of RES against CAR-induced alteration in reproductive parameters of male rats. Methods: In this experimental study, 48 male rats were randomly assigned to eight groups: Group 1: Normal control (saline) group; Group 2: CAR control (250 mg/kg) group; Groups 3–5: 2, 8, and 20 mg/kg RES, respectively, groups; Groups 6–8: CAR plus 2, 8, and 20 mg/kg RES, respectively, groups. The agents were administered intraperitoneally and by gavage daily for 65 days. Sperm parameters, testis malondialdehyde (MDA) levels, total antioxidant capacity, testosterone levels, and germinal layer height were evaluated and compared among these groups. Results: No significant alterations were observed in RES groups (with different doses) compared to the normal control group (P > 0.05). The levels of all parameters except MDA (which decreased) significantly increased in the CAR plus RES (with different doses) groups compared to the CAR control group (P < 0.01). Conclusions: RES attenuates the toxic effect of CAR on some of the male reproductive parameters.http://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=4;spage=222;epage=229;aulast=Jalilicarbophos; resveratrol; testopathy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cyrus Jalili Shiva Roshankhah Azita Faramarzi Mohammad Reza Salahshoor |
spellingShingle |
Cyrus Jalili Shiva Roshankhah Azita Faramarzi Mohammad Reza Salahshoor Effects of carbophos on rat testopathy following resveratrol administration: An experimental study Reproductive and Developmental Medicine carbophos; resveratrol; testopathy |
author_facet |
Cyrus Jalili Shiva Roshankhah Azita Faramarzi Mohammad Reza Salahshoor |
author_sort |
Cyrus Jalili |
title |
Effects of carbophos on rat testopathy following resveratrol administration: An experimental study |
title_short |
Effects of carbophos on rat testopathy following resveratrol administration: An experimental study |
title_full |
Effects of carbophos on rat testopathy following resveratrol administration: An experimental study |
title_fullStr |
Effects of carbophos on rat testopathy following resveratrol administration: An experimental study |
title_full_unstemmed |
Effects of carbophos on rat testopathy following resveratrol administration: An experimental study |
title_sort |
effects of carbophos on rat testopathy following resveratrol administration: an experimental study |
publisher |
Wolters Kluwer Medknow Publications |
series |
Reproductive and Developmental Medicine |
issn |
2096-2924 2589-8728 |
publishDate |
2019-01-01 |
description |
Objective: Carbophos (CAR) is an organophosphate that is most capable of producing free radicals and inducing alteration in some of the male reproductive parameters. Resveratrol (RES) is an herbal polyphenol and exerts beneficial antioxidant effects. This study aimed to evaluate the effects of RES against CAR-induced alteration in reproductive parameters of male rats.
Methods: In this experimental study, 48 male rats were randomly assigned to eight groups: Group 1: Normal control (saline) group; Group 2: CAR control (250 mg/kg) group; Groups 3–5: 2, 8, and 20 mg/kg RES, respectively, groups; Groups 6–8: CAR plus 2, 8, and 20 mg/kg RES, respectively, groups. The agents were administered intraperitoneally and by gavage daily for 65 days. Sperm parameters, testis malondialdehyde (MDA) levels, total antioxidant capacity, testosterone levels, and germinal layer height were evaluated and compared among these groups.
Results: No significant alterations were observed in RES groups (with different doses) compared to the normal control group (P > 0.05). The levels of all parameters except MDA (which decreased) significantly increased in the CAR plus RES (with different doses) groups compared to the CAR control group (P < 0.01).
Conclusions: RES attenuates the toxic effect of CAR on some of the male reproductive parameters. |
topic |
carbophos; resveratrol; testopathy |
url |
http://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=4;spage=222;epage=229;aulast=Jalili |
work_keys_str_mv |
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