Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus
Background: The value of cerebrospinal fluid (CSF) biomarkers for assessing idiopathic normal pressure hydrocephalus (iNPH) must be determined. This prospective study aimed to reveal the correlation between CSF biomarkers and clinical symptoms of iNPH and the predictive value of these biomarkers for...
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2021-05-01
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doaj-b3550e99c82e405b8d97bcb768edc0ad2021-05-20T04:14:19ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-05-011310.3389/fnagi.2021.665878665878Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure HydrocephalusRongrong Hua0Chunyan Liu1Xing Liu2Jinwu Zhu3Jie Zhang4Lidong Wang5Zhe Shi6Jian Li7Shuangyan Kong8Chenhui Yang9Nan Liu10Lijuan Liu11Jie Sun12Qiong Yang13Yubing Wu14Ying Zhou15Yanfeng Li16Yan Xing17Department of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaAviation Medical Engineering Center of Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Neurology, Aviation General Hospital, Beijing, ChinaBackground: The value of cerebrospinal fluid (CSF) biomarkers for assessing idiopathic normal pressure hydrocephalus (iNPH) must be determined. This prospective study aimed to reveal the correlation between CSF biomarkers and clinical symptoms of iNPH and the predictive value of these biomarkers for tap test responsiveness.Methods: Thirty-nine patients with suspected iNPH were recruited, contributed qualified CSF, and underwent a tap test and unified pre- and post-test evaluations of the neurological function.Results: The analysis of biomarkers from the patients’ CSF showed decreased levels of tau and its phosphorylated form, especially in the tap test (+) group. The responsiveness of the tap test was also related to the number of combined symptoms (p < 0.01), and a correlation was found between the end pressure or pressure difference in CSF and tap test responsiveness (p < 0.05). The results of the binary logistic regression analysis showed that P (tap test responsiveness) = 1/1 + e∧ − (−5.505 + 55.314 * ratio of p/T-tau − 1.586 * numbers of combined symptoms). The combined indicators (−5.505 + 0.553 * percentage of p/T-tau − 1.586 * numbers of combined symptoms) resulted in the highest sensitivity and specificity of 94.12% and 72.73%, respectively.Conclusions: CSF biomarkers may be assessed to judge tap test responsiveness, which is beneficial for the feasibility of a clinical application.https://www.frontiersin.org/articles/10.3389/fnagi.2021.665878/fullidiopathic normal pressure hydrocephaluscerebrospinal fluid biomarkerstap testtauAβ |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rongrong Hua Chunyan Liu Xing Liu Jinwu Zhu Jie Zhang Lidong Wang Zhe Shi Jian Li Shuangyan Kong Chenhui Yang Nan Liu Lijuan Liu Jie Sun Qiong Yang Yubing Wu Ying Zhou Yanfeng Li Yan Xing |
spellingShingle |
Rongrong Hua Chunyan Liu Xing Liu Jinwu Zhu Jie Zhang Lidong Wang Zhe Shi Jian Li Shuangyan Kong Chenhui Yang Nan Liu Lijuan Liu Jie Sun Qiong Yang Yubing Wu Ying Zhou Yanfeng Li Yan Xing Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus Frontiers in Aging Neuroscience idiopathic normal pressure hydrocephalus cerebrospinal fluid biomarkers tap test tau Aβ |
author_facet |
Rongrong Hua Chunyan Liu Xing Liu Jinwu Zhu Jie Zhang Lidong Wang Zhe Shi Jian Li Shuangyan Kong Chenhui Yang Nan Liu Lijuan Liu Jie Sun Qiong Yang Yubing Wu Ying Zhou Yanfeng Li Yan Xing |
author_sort |
Rongrong Hua |
title |
Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus |
title_short |
Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus |
title_full |
Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus |
title_fullStr |
Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus |
title_full_unstemmed |
Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus |
title_sort |
predictive value of cerebrospinal fluid biomarkers for tap test responsiveness in patients with suspected idiopathic normal pressure hydrocephalus |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-05-01 |
description |
Background: The value of cerebrospinal fluid (CSF) biomarkers for assessing idiopathic normal pressure hydrocephalus (iNPH) must be determined. This prospective study aimed to reveal the correlation between CSF biomarkers and clinical symptoms of iNPH and the predictive value of these biomarkers for tap test responsiveness.Methods: Thirty-nine patients with suspected iNPH were recruited, contributed qualified CSF, and underwent a tap test and unified pre- and post-test evaluations of the neurological function.Results: The analysis of biomarkers from the patients’ CSF showed decreased levels of tau and its phosphorylated form, especially in the tap test (+) group. The responsiveness of the tap test was also related to the number of combined symptoms (p < 0.01), and a correlation was found between the end pressure or pressure difference in CSF and tap test responsiveness (p < 0.05). The results of the binary logistic regression analysis showed that P (tap test responsiveness) = 1/1 + e∧ − (−5.505 + 55.314 * ratio of p/T-tau − 1.586 * numbers of combined symptoms). The combined indicators (−5.505 + 0.553 * percentage of p/T-tau − 1.586 * numbers of combined symptoms) resulted in the highest sensitivity and specificity of 94.12% and 72.73%, respectively.Conclusions: CSF biomarkers may be assessed to judge tap test responsiveness, which is beneficial for the feasibility of a clinical application. |
topic |
idiopathic normal pressure hydrocephalus cerebrospinal fluid biomarkers tap test tau Aβ |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.665878/full |
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