Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan
Introduction. Hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm of the liver. During the early stages, HCC is asymptomatic, which makes X-ray examination a particularly important diagnostic tool. According to WHO data, the mortality rate from HCC was 782,000 in 2018. HCC i...
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Bashkir State Medical University
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doaj-b35ba3b1aa6c4ec69ae73e35bfd98b522021-07-28T13:20:40ZengBashkir State Medical UniversityКреативная хирургия и онкология2307-05012076-30932020-11-0110318318910.24060/2076-3093-2020-10-3-183-189385Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of BashkortostanSh. Kh. Gantsev0O. N. Lipatov1K. V. Menshikov2D. S. Tursumetov3Kh. S. Saydulaeva4Bashkir State Medical UniversityBashkir State Medical UniversityBashkir State Medical University; Republican Clinical Oncological DispensaryBashkir State Medical UniversityBashkir State Medical University; Republican Clinical Oncological DispensaryIntroduction. Hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm of the liver. During the early stages, HCC is asymptomatic, which makes X-ray examination a particularly important diagnostic tool. According to WHO data, the mortality rate from HCC was 782,000 in 2018. HCC is associated with a number of risk factors: a high viral load, liver cirrhosis, detected HBeAg and elevated serum HBsAg levels. Inhibitors of tyrosine kinase receptors increase the overall survival and progression-free survival rates in patients with metastatic HCC. In this article, we conduct an analysis of results of the REFLECT study obtained for Russian patients by the Republican Clinical Oncological Dispensary, Ufa.Materials and methods. The experimental group included 9 patients (52.9%) receiving Lenvatinib. The control group included 8 patients (47.1%)) underwent therapy with Sorafenib at a dose of 800 mg per day 7 (41.17%) patients had a history of chronic hepatitis, of which hepatitis B and chronic hepatitis C was confirmed in 6 and 1 cases, respectively.Results and discussion. Over the period from 2017 up to the present, progression-free survival was observed in three patients (17.6%), of which 2 and 1 received Lenvatinib and Sorafenib, respectively. Overall survival was 10.5 months. The median overall survival rate in the experimental and control groups was 9.8 and 11.2 months, respectively. These parameters are considered comparable, provided that the sample was small.Conclusions. The use of Lenvatinib demonstrated the efficacy comparable to that of Sorafenib in terms of the overall survival rate in patients with inoperable HCC. Lenvatinib allowed statistically and clinically significant improvement in the progression-free survival and time to progression to be achieved.https://www.surgonco.ru/jour/article/view/503liver neoplasmshepatocellular carcinomaviral hepatitistyrosine kinase inhibitorstargeted therapymetastaseslenvatinibsorafenib |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sh. Kh. Gantsev O. N. Lipatov K. V. Menshikov D. S. Tursumetov Kh. S. Saydulaeva |
spellingShingle |
Sh. Kh. Gantsev O. N. Lipatov K. V. Menshikov D. S. Tursumetov Kh. S. Saydulaeva Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan Креативная хирургия и онкология liver neoplasms hepatocellular carcinoma viral hepatitis tyrosine kinase inhibitors targeted therapy metastases lenvatinib sorafenib |
author_facet |
Sh. Kh. Gantsev O. N. Lipatov K. V. Menshikov D. S. Tursumetov Kh. S. Saydulaeva |
author_sort |
Sh. Kh. Gantsev |
title |
Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan |
title_short |
Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan |
title_full |
Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan |
title_fullStr |
Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan |
title_full_unstemmed |
Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan |
title_sort |
experience of hepatocellular cancer therapy with multikinase inhibitors in the republic of bashkortostan |
publisher |
Bashkir State Medical University |
series |
Креативная хирургия и онкология |
issn |
2307-0501 2076-3093 |
publishDate |
2020-11-01 |
description |
Introduction. Hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm of the liver. During the early stages, HCC is asymptomatic, which makes X-ray examination a particularly important diagnostic tool. According to WHO data, the mortality rate from HCC was 782,000 in 2018. HCC is associated with a number of risk factors: a high viral load, liver cirrhosis, detected HBeAg and elevated serum HBsAg levels. Inhibitors of tyrosine kinase receptors increase the overall survival and progression-free survival rates in patients with metastatic HCC. In this article, we conduct an analysis of results of the REFLECT study obtained for Russian patients by the Republican Clinical Oncological Dispensary, Ufa.Materials and methods. The experimental group included 9 patients (52.9%) receiving Lenvatinib. The control group included 8 patients (47.1%)) underwent therapy with Sorafenib at a dose of 800 mg per day 7 (41.17%) patients had a history of chronic hepatitis, of which hepatitis B and chronic hepatitis C was confirmed in 6 and 1 cases, respectively.Results and discussion. Over the period from 2017 up to the present, progression-free survival was observed in three patients (17.6%), of which 2 and 1 received Lenvatinib and Sorafenib, respectively. Overall survival was 10.5 months. The median overall survival rate in the experimental and control groups was 9.8 and 11.2 months, respectively. These parameters are considered comparable, provided that the sample was small.Conclusions. The use of Lenvatinib demonstrated the efficacy comparable to that of Sorafenib in terms of the overall survival rate in patients with inoperable HCC. Lenvatinib allowed statistically and clinically significant improvement in the progression-free survival and time to progression to be achieved. |
topic |
liver neoplasms hepatocellular carcinoma viral hepatitis tyrosine kinase inhibitors targeted therapy metastases lenvatinib sorafenib |
url |
https://www.surgonco.ru/jour/article/view/503 |
work_keys_str_mv |
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