Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats

Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats

We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were responsible for negative mechanical restitution in these myocytes. PAH...

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Bibliographic Details
Main Authors: Matthew E. L. Hardy, Eleftheria Pervolaraki, Olivier Bernus, Ed White
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
pulmonary artery hypertension
APD restitution
mechanical restitution
right heart failure
action potential clamp
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00205/full

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