Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?
Abstract Introduction The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. Methods For 20 existing [18F]GE-179 datasets, we generated (1) standar...
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doaj-b3680a97467645028a5c8946536bcd392020-11-25T00:46:12ZengSpringerOpenEJNMMI Research2191-219X2018-06-01811810.1186/s13550-018-0396-2Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?Colm J. McGinnity0Daniela A. Riaño Barros1William Trigg2David J. Brooks3Rainer Hinz4John S. Duncan5Matthias J. Koepp6Alexander Hammers7Division of Brain Sciences, Imperial College LondonDivision of Brain Sciences, Imperial College LondonGE Healthcare LtdDepartment of Nuclear Medicine, Aarhus UniversityWolfson Molecular Imaging Centre, University of ManchesterDepartment of Clinical and Experimental Epilepsy, UCL Institute of NeurologyDepartment of Clinical and Experimental Epilepsy, UCL Institute of NeurologyDivision of Brain Sciences, Imperial College LondonAbstract Introduction The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. Methods For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (V T) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) V T images using three shortened datasets, using the original parent plasma input functions (ppIFs). Results Correlations with the original ppIF-derived 90-min V Ts increased for later interval SUVs (maximal ρ = 0.78; 80–90 min). They were strong for PBIF-derived V Ts (ρ = 0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived V Ts (ρ = 0.97–1.00), which suffered regionally variant negative bias. Conclusions Where arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived V Ts.http://link.springer.com/article/10.1186/s13550-018-0396-2NMDAPETCompartmental modellingCNS-5161SUV |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Colm J. McGinnity Daniela A. Riaño Barros William Trigg David J. Brooks Rainer Hinz John S. Duncan Matthias J. Koepp Alexander Hammers |
spellingShingle |
Colm J. McGinnity Daniela A. Riaño Barros William Trigg David J. Brooks Rainer Hinz John S. Duncan Matthias J. Koepp Alexander Hammers Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? EJNMMI Research NMDA PET Compartmental modelling CNS-5161 SUV |
author_facet |
Colm J. McGinnity Daniela A. Riaño Barros William Trigg David J. Brooks Rainer Hinz John S. Duncan Matthias J. Koepp Alexander Hammers |
author_sort |
Colm J. McGinnity |
title |
Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? |
title_short |
Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? |
title_full |
Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? |
title_fullStr |
Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? |
title_full_unstemmed |
Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? |
title_sort |
simplifying [18f]ge-179 pet: are both arterial blood sampling and 90-min acquisitions essential? |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2018-06-01 |
description |
Abstract Introduction The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. Methods For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (V T) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) V T images using three shortened datasets, using the original parent plasma input functions (ppIFs). Results Correlations with the original ppIF-derived 90-min V Ts increased for later interval SUVs (maximal ρ = 0.78; 80–90 min). They were strong for PBIF-derived V Ts (ρ = 0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived V Ts (ρ = 0.97–1.00), which suffered regionally variant negative bias. Conclusions Where arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived V Ts. |
topic |
NMDA PET Compartmental modelling CNS-5161 SUV |
url |
http://link.springer.com/article/10.1186/s13550-018-0396-2 |
work_keys_str_mv |
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