Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and that the complex interacts with different lineage spe...
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Nature Publishing Group
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19328-1 |
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doaj-b36e0ab4d6324855a87fa9ba1ed5cc3e2021-05-11T08:23:35ZengNature Publishing GroupNature Communications2041-17232020-11-0111111610.1038/s41467-020-19328-1Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticityJoanna Cyrta0Anke Augspach1Maria Rosaria De Filippo2Davide Prandi3Phillip Thienger4Matteo Benelli5Victoria Cooley6Rohan Bareja7David Wilkes8Sung-Suk Chae9Paola Cavaliere10Noah Dephoure11Anne-Christine Uldry12Sophie Braga Lagache13Luca Roma14Sandra Cohen15Muriel Jaquet16Laura P. Brandt17Mohammed Alshalalfa18Loredana Puca19Andrea Sboner20Felix Feng21Shangqian Wang22Himisha Beltran23Tamara Lotan24Martin Spahn25Marianna Kruithof-de Julio26Yu Chen27Karla V. Ballman28Francesca Demichelis29Salvatore Piscuoglio30Mark A. Rubin31Department for BioMedical Research, University of BernDepartment for BioMedical Research, University of BernDepartment for BioMedical Research, Urology Research Laboratory, University of BernDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of TrentoDepartment for BioMedical Research, University of BernDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of TrentoDepartment of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell MedicineThe Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell MedicineThe Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell MedicineDepartment of Laboratory Medicine and Pathology, Weill Cornell MedicineMeyer Cancer Center, Weill Cornell MedicineMeyer Cancer Center, Weill Cornell MedicineProteomics Mass Spectrometry Core Facility, University of BernProteomics Mass Spectrometry Core Facility, University of BernInstitute of Pathology and Medical Genetics, University Hospital Basel, University of BaselDepartment of Laboratory Medicine and Pathology, Weill Cornell MedicineDepartment for BioMedical Research, University of BernDepartment for BioMedical Research, University of BernDepartment of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California at San FranciscoDepartment of Medicine, Division of Medical Oncology, Weill Cornell MedicineThe Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell MedicineProteomics Mass Spectrometry Core Facility, University of BernHuman Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan-Kettering Cancer CenterDepartment of Medicine, Division of Medical Oncology, Weill Cornell MedicineDepartment of Urology, Johns Hopkins University School of MedicineLindenhofspital Bern, Prostate Center BernDepartment for BioMedical Research, University of BernDepartment of Medicine, Division of Medical Oncology, Weill Cornell MedicineDepartment of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell MedicineThe Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell MedicineInstitute of Pathology and Medical Genetics, University Hospital Basel, University of BaselDepartment for BioMedical Research, University of BernThe differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and that the complex interacts with different lineage specific factors throughout prostate cancer transdifferentiation.https://doi.org/10.1038/s41467-020-19328-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Joanna Cyrta Anke Augspach Maria Rosaria De Filippo Davide Prandi Phillip Thienger Matteo Benelli Victoria Cooley Rohan Bareja David Wilkes Sung-Suk Chae Paola Cavaliere Noah Dephoure Anne-Christine Uldry Sophie Braga Lagache Luca Roma Sandra Cohen Muriel Jaquet Laura P. Brandt Mohammed Alshalalfa Loredana Puca Andrea Sboner Felix Feng Shangqian Wang Himisha Beltran Tamara Lotan Martin Spahn Marianna Kruithof-de Julio Yu Chen Karla V. Ballman Francesca Demichelis Salvatore Piscuoglio Mark A. Rubin |
| spellingShingle |
Joanna Cyrta Anke Augspach Maria Rosaria De Filippo Davide Prandi Phillip Thienger Matteo Benelli Victoria Cooley Rohan Bareja David Wilkes Sung-Suk Chae Paola Cavaliere Noah Dephoure Anne-Christine Uldry Sophie Braga Lagache Luca Roma Sandra Cohen Muriel Jaquet Laura P. Brandt Mohammed Alshalalfa Loredana Puca Andrea Sboner Felix Feng Shangqian Wang Himisha Beltran Tamara Lotan Martin Spahn Marianna Kruithof-de Julio Yu Chen Karla V. Ballman Francesca Demichelis Salvatore Piscuoglio Mark A. Rubin Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity Nature Communications |
| author_facet |
Joanna Cyrta Anke Augspach Maria Rosaria De Filippo Davide Prandi Phillip Thienger Matteo Benelli Victoria Cooley Rohan Bareja David Wilkes Sung-Suk Chae Paola Cavaliere Noah Dephoure Anne-Christine Uldry Sophie Braga Lagache Luca Roma Sandra Cohen Muriel Jaquet Laura P. Brandt Mohammed Alshalalfa Loredana Puca Andrea Sboner Felix Feng Shangqian Wang Himisha Beltran Tamara Lotan Martin Spahn Marianna Kruithof-de Julio Yu Chen Karla V. Ballman Francesca Demichelis Salvatore Piscuoglio Mark A. Rubin |
| author_sort |
Joanna Cyrta |
| title |
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity |
| title_short |
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity |
| title_full |
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity |
| title_fullStr |
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity |
| title_full_unstemmed |
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity |
| title_sort |
role of specialized composition of swi/snf complexes in prostate cancer lineage plasticity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and that the complex interacts with different lineage specific factors throughout prostate cancer transdifferentiation. |
| url |
https://doi.org/10.1038/s41467-020-19328-1 |
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