Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.
Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood.Here we addressed this deficiency by transcriptionally profiling...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2671160?pdf=render |
id |
doaj-b37ffd2a672949a59027720c2b7d2992 |
---|---|
record_format |
Article |
spelling |
doaj-b37ffd2a672949a59027720c2b7d29922020-11-25T01:41:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0144e540110.1371/journal.pone.0005401Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.Don L GibbonsWei LinChad J CreightonShuling ZhengDror BerelYanan YangMaria Gabriela RasoDiane D LiuIgnacio I WistubaGuillermina LozanoJonathan M KurieNon-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood.Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-ras(G12D) and p53(R172H). We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature.These findings provide evidence that K-ras(G12D); p53(R172H) mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents.http://europepmc.org/articles/PMC2671160?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Don L Gibbons Wei Lin Chad J Creighton Shuling Zheng Dror Berel Yanan Yang Maria Gabriela Raso Diane D Liu Ignacio I Wistuba Guillermina Lozano Jonathan M Kurie |
spellingShingle |
Don L Gibbons Wei Lin Chad J Creighton Shuling Zheng Dror Berel Yanan Yang Maria Gabriela Raso Diane D Liu Ignacio I Wistuba Guillermina Lozano Jonathan M Kurie Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS ONE |
author_facet |
Don L Gibbons Wei Lin Chad J Creighton Shuling Zheng Dror Berel Yanan Yang Maria Gabriela Raso Diane D Liu Ignacio I Wistuba Guillermina Lozano Jonathan M Kurie |
author_sort |
Don L Gibbons |
title |
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. |
title_short |
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. |
title_full |
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. |
title_fullStr |
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. |
title_full_unstemmed |
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. |
title_sort |
expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2009-01-01 |
description |
Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood.Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-ras(G12D) and p53(R172H). We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature.These findings provide evidence that K-ras(G12D); p53(R172H) mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents. |
url |
http://europepmc.org/articles/PMC2671160?pdf=render |
work_keys_str_mv |
AT donlgibbons expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT weilin expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT chadjcreighton expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT shulingzheng expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT drorberel expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT yananyang expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT mariagabrielaraso expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT dianedliu expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT ignacioiwistuba expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT guillerminalozano expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma AT jonathanmkurie expressionsignaturesofmetastaticcapacityinageneticmousemodeloflungadenocarcinoma |
_version_ |
1725040024011931648 |