Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1.

Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1.

Thy-1 is a membrane glycoprotein suggested to stabilize or inhibit growth of neuronal processes. However, its precise function has remained obscure, because its endogenous ligand is unknown. We previously showed that Thy-1 binds directly to α(V)β(3) integrin in trans eliciting responses in astrocyte...

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Bibliographic Details
Main Authors: Rodrigo Herrera-Molina, Renato Frischknecht, Horacio Maldonado, Constanze I Seidenbecher, Eckart D Gundelfinger, Claudio Hetz, María de la Luz Aylwin, Pascal Schneider, Andrew F G Quest, Lisette Leyton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316703?pdf=render

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