Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors
Digestive tract tumors account for 15% and 19.3% of the cancer incidence and deaths, respectively. Early detection of digestive tract tumors is crucial to the reduction of global cancer burden. Two-photon excitation fluorescence lifetime imaging microscopy (TP-FLIM) allows non-invasive, label-free,...
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World Scientific Publishing
2019-09-01
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doaj-b38c5014b3254efbb306c5a0460822bb2020-11-24T22:01:03ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052019-09-011251930009-11930009-1610.1142/S179354581930009X10.1142/S179354581930009XTwo-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumorsHui Li0Jia Yu1Rongli Zhang2Xi Li3Wei Zheng4Research Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, P. R. ChinaResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, P. R. ChinaResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, P. R. ChinaDepartment of Gastroenterology, Peking University Shenzhen Hospital, Shen Zhen, Guangdong 518036, P. R. ChinaResearch Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, P. R. ChinaDigestive tract tumors account for 15% and 19.3% of the cancer incidence and deaths, respectively. Early detection of digestive tract tumors is crucial to the reduction of global cancer burden. Two-photon excitation fluorescence lifetime imaging microscopy (TP-FLIM) allows non-invasive, label-free, three-dimensional, high-resolution imaging of living tissues with not only histological but also biochemical characterization ability in both qualitative and quantitative way. Benefiting from these advantages, this technology is promising for clinical diagnosis of digestive tract tumors. In recent years, many efforts have been made in this field and some remarkable progress has been achieved. In this paper, we overview the recent progress of TP-FLIM-based researches on digestive tract tumor detection. Among them, our latest results on the gastric cancer and esophageal cancer are elaborately depicted. Finally, we outlook and discuss the potential advantages and challenges of TP-FLIM in future clinical applications.http://www.worldscientific.com/doi/pdf/10.1142/S179354581930009XTwo-photon excitation fluorescence microscopyfluorescence lifetimefluorescence spectrumdigestive tract tumor diagnosisautofluorescence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui Li Jia Yu Rongli Zhang Xi Li Wei Zheng |
spellingShingle |
Hui Li Jia Yu Rongli Zhang Xi Li Wei Zheng Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors Journal of Innovative Optical Health Sciences Two-photon excitation fluorescence microscopy fluorescence lifetime fluorescence spectrum digestive tract tumor diagnosis autofluorescence |
author_facet |
Hui Li Jia Yu Rongli Zhang Xi Li Wei Zheng |
author_sort |
Hui Li |
title |
Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors |
title_short |
Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors |
title_full |
Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors |
title_fullStr |
Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors |
title_full_unstemmed |
Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors |
title_sort |
two-photon excitation fluorescence lifetime imaging microscopy: a promising diagnostic tool for digestive tract tumors |
publisher |
World Scientific Publishing |
series |
Journal of Innovative Optical Health Sciences |
issn |
1793-5458 1793-7205 |
publishDate |
2019-09-01 |
description |
Digestive tract tumors account for 15% and 19.3% of the cancer incidence and deaths, respectively. Early detection of digestive tract tumors is crucial to the reduction of global cancer burden. Two-photon excitation fluorescence lifetime imaging microscopy (TP-FLIM) allows non-invasive, label-free, three-dimensional, high-resolution imaging of living tissues with not only histological but also biochemical characterization ability in both qualitative and quantitative way. Benefiting from these advantages, this technology is promising for clinical diagnosis of digestive tract tumors. In recent years, many efforts have been made in this field and some remarkable progress has been achieved. In this paper, we overview the recent progress of TP-FLIM-based researches on digestive tract tumor detection. Among them, our latest results on the gastric cancer and esophageal cancer are elaborately depicted. Finally, we outlook and discuss the potential advantages and challenges of TP-FLIM in future clinical applications. |
topic |
Two-photon excitation fluorescence microscopy fluorescence lifetime fluorescence spectrum digestive tract tumor diagnosis autofluorescence |
url |
http://www.worldscientific.com/doi/pdf/10.1142/S179354581930009X |
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