Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies

Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies

Abstract Background Adherence is critical for successful topical, vaginally delivered anti-retroviral (ARV)-based HIV pre-exposure prophylaxis (PrEP). Quantitating systemic or tissue ARV levels through LC–MS/MS is currently viewed as the most reliable measure of adherence. However, for placebo-contr...

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Bibliographic Details
Main Authors: Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Abby G. Peele, Susan Ju, Jill L. Schwartz, Andrea R. Thurman, Gustavo F. Doncel
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:Clinical and Translational Medicine
Subjects:
Adherence
HIV
PrEP
placebo
Spectroscopy
Microbicides
Online Access:http://link.springer.com/article/10.1186/s40169-018-0213-6

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