Substrate stiffness affects early differentiation events in embryonic stem cells

Substrate stiffness affects early differentiation events in embryonic stem cells

Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement therapies and an accessible tool to model early embryonic development. Chemical factors such as soluble growth factors and insoluble components of the extracellular matrix are known to affect the differentiation o...

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Bibliographic Details
Main Authors: ND Evans, C Minelli, E Gentleman, V LaPointe, SN Patankar, M Kallivretaki, X Chen, CJ Roberts, MM Stevens
Format: Article
Language:English
Published: AO Research Institute Davos 2009-09-01
Series:European Cells & Materials
Subjects:
Embryonic stem cells
cellular mechanotransduction
gastrulation
extracellular matrix
differentiation
mammalian development
Online Access:http://www.ecmjournal.org/journal/papers/vol018/pdf/v018a01.pdf

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