Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, glios...

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Main Authors: Ting Zou, Lixiong Gao, Yuxiao Zeng, Qiyou Li, Yijian Li, Siyu Chen, Xisu Hu, Xi Chen, Caiyun Fu, Haiwei Xu, Zheng Qin Yin
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08961-0
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spelling doaj-b3a0a613f39d4b1d8b06d83729d562162021-05-11T11:49:01ZengNature Publishing GroupNature Communications2041-17232019-03-0110111710.1038/s41467-019-08961-0Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodentsTing Zou0Lixiong Gao1Yuxiao Zeng2Qiyou Li3Yijian Li4Siyu Chen5Xisu Hu6Xi Chen7Caiyun Fu8Haiwei Xu9Zheng Qin Yin10Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University)Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, gliosis and inflammation.https://doi.org/10.1038/s41467-019-08961-0
collection DOAJ
language English
format Article
sources DOAJ
author Ting Zou
Lixiong Gao
Yuxiao Zeng
Qiyou Li
Yijian Li
Siyu Chen
Xisu Hu
Xi Chen
Caiyun Fu
Haiwei Xu
Zheng Qin Yin
spellingShingle Ting Zou
Lixiong Gao
Yuxiao Zeng
Qiyou Li
Yijian Li
Siyu Chen
Xisu Hu
Xi Chen
Caiyun Fu
Haiwei Xu
Zheng Qin Yin
Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
Nature Communications
author_facet Ting Zou
Lixiong Gao
Yuxiao Zeng
Qiyou Li
Yijian Li
Siyu Chen
Xisu Hu
Xi Chen
Caiyun Fu
Haiwei Xu
Zheng Qin Yin
author_sort Ting Zou
title Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_short Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_full Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_fullStr Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_full_unstemmed Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_sort organoid-derived c-kit+/ssea4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, gliosis and inflammation.
url https://doi.org/10.1038/s41467-019-08961-0
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