Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer

Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with roles in inflammation and tumorigenicity. A fraction of STAT3 localizes in mitochondria, where it augments tumorigenesis via regulation of mitochondrial functions, including modulation of respiration and redox...

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Bibliographic Details
Main Authors: Tanaya Lahiri, Lara Brambilla, Joshua Andrade, Manor Askenazi, Beatrix Ueberheide, David E. Levy
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Molecular Oncology
Subjects:
breast cancer
glutathione
mitochondria
oxidative stress
reactive oxygen species
STAT3
Online Access:https://doi.org/10.1002/1878-0261.12928

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