Correlation of intestinal flora disturbance with immune response and inflammatory response in patients with MODS

• Main Author: Zhao-Jie Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-07-01
• Series: Journal of Hainan Medical University
• Subjects: Multiple organ dysfunction syndrome; Intestinal flora disturbance; Immune response; Inflammatory response
• Online Access: http://www.hnykdxxb.com/PDF/201713/13.pdf

Objective: To study the correlation of intestinal flora disturbance with immune response and inflammatory response in patients with MODS. Methods: 60 patients with MODS who were treated in our hospital between August 2013 and January 2017 were collected as the observation group, and 50 healthy subjects who received physical examination in our hospital during the same period were collected as normal control group. The differences in intestinal flora distribution in the feces samples, peripheral blood contents of T lymphocyte subsets and serum levels of immunoglobulin and inflammatory factors were compared between two groups of subjects. The relationship of intestinal flora distribution with immune response and inflammatory response was assessed by Pearson test. Results: Bifidobacterium and lactobacillus count as well as B/E value in feces of observation group were lower than those of normal control group while escherichia coli and enterococcus count were higher than those of normal control group; peripheral blood CD4+T lymphocyte proportion and CD4+/CD8+ratio were lower than those of normal control group while CD8+T lymphocyte proportion was higher than that of normal control group; serum immunoglobulin IgA, IgM and IgG levels were lower than those of normal control group; serum inflammatory factors PCT, IL-1, IL-6, IL-8 and TNF-α levels were higher than those of normal control group. Pearson test showed that the intestinal flora disturbance in patients with MODS is directly correlated with the immune response function and inflammatory response. Conclusion: There is obvious intestinal flora disturbance in patients with MODS, and it is one of the important causes of immune function injury and systemic inflammatory response in patients.