Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase
Chagas’ disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the “active-to-hit” stage. However, only a more limited number of these have been...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-03-01
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| Series: | Pharmaceuticals |
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| Online Access: | http://www.mdpi.com/1424-8247/3/4/810/ |
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Article |
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doaj-b3b6434b7b4246b29123657436122b792020-11-25T02:50:12ZengMDPI AGPharmaceuticals1424-82472010-03-013481083810.3390/ph3040810Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” PhaseHugo CerecettoMercedes GonzálezChagas’ disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the “active-to-hit” stage. However, only a more limited number of these have been studied in vivo in models of Chagas’ disease. Herein, we survey some of the cantidates able to surpass the “hit-to-lead” stage discussing their limitations or merit to enter in clinical trials in the short term. http://www.mdpi.com/1424-8247/3/4/810/Chagas’ disease“hit-to-lead”drug-likeness |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hugo Cerecetto Mercedes González |
| spellingShingle |
Hugo Cerecetto Mercedes González Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase Pharmaceuticals Chagas’ disease “hit-to-lead” drug-likeness |
| author_facet |
Hugo Cerecetto Mercedes González |
| author_sort |
Hugo Cerecetto |
| title |
Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase |
| title_short |
Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase |
| title_full |
Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase |
| title_fullStr |
Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase |
| title_full_unstemmed |
Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase |
| title_sort |
synthetic medicinal chemistry in chagas’ disease: compounds at the final stage of “hit-to-lead” phase |
| publisher |
MDPI AG |
| series |
Pharmaceuticals |
| issn |
1424-8247 |
| publishDate |
2010-03-01 |
| description |
Chagas’ disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the “active-to-hit” stage. However, only a more limited number of these have been studied in vivo in models of Chagas’ disease. Herein, we survey some of the cantidates able to surpass the “hit-to-lead” stage discussing their limitations or merit to enter in clinical trials in the short term. |
| topic |
Chagas’ disease “hit-to-lead” drug-likeness |
| url |
http://www.mdpi.com/1424-8247/3/4/810/ |
| work_keys_str_mv |
AT hugocerecetto syntheticmedicinalchemistryinchagasdiseasecompoundsatthefinalstageofhittoleadphase AT mercedesgonzalez syntheticmedicinalchemistryinchagasdiseasecompoundsatthefinalstageofhittoleadphase |
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