Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy
Background and purpose: To evaluate the influence of delays for radiotherapy on survival, recurrence and upstaging for head and neck squamous-cell carcinoma (HNSCC) with no nodal involvement treated with intensity modulated radiotherapy (IMRT). Material and methods: This retrospective study included...
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doaj-b3bdd76adb134df7978c8836c2e9c03b2021-06-02T08:45:14ZengElsevierClinical and Translational Radiation Oncology2405-63082016-12-011C273210.1016/j.ctro.2016.11.002Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapyCédric Chevalier0Aurélie Bertaut1Magali Quivrin2Noémie Vulquin3Cédric Desandes4Mireille Folia5Christian Duvillard6Gilles Truc7Gilles Crehange8Philippe Maingon9Department of Radiation Oncology, Georges François Leclerc Cancer Center, Dijon, FranceDepartment of Statistics, Georges François Leclerc Cancer Center, Dijon, FranceDepartment of Radiation Oncology, Georges François Leclerc Cancer Center, Dijon, FranceDepartment of Radiation Oncology, Georges François Leclerc Cancer Center, Dijon, FranceDepartment of Radiation Oncology, Georges François Leclerc Cancer Center, Dijon, FranceEar Nose and Throat Department, University Hospital of Dijon, Dijon, FranceEar Nose and Throat Department, University Hospital of Dijon, Dijon, FranceDepartment of Radiation Oncology, Georges François Leclerc Cancer Center, Dijon, FranceDepartment of Radiation Oncology, Georges François Leclerc Cancer Center, Dijon, FranceRadiation Oncology Department, GHU La Pitié Salpêtrière, Paris, FranceBackground and purpose: To evaluate the influence of delays for radiotherapy on survival, recurrence and upstaging for head and neck squamous-cell carcinoma (HNSCC) with no nodal involvement treated with intensity modulated radiotherapy (IMRT). Material and methods: This retrospective study included 63 consecutive patients with HNSCC located in the pharynx and larynx and treated with exclusive IMRT with or without chemotherapy. Survival, loco-regional or distant failure and upstaging were analyzed according to the waiting time. Results: Mean waiting time for treatment was 62.5 days for the hypopharynx subgroup (range = 37–102), 63 days for the larynx subgroup (range = 19–128) and 58.5 days for the oropharynx subgroup (range = 29–99) (p = 0.725). Nine patients (14%) experienced upstaging. Loco-regional or distant failure occurred in 18 patients. Beyond a delay of 50 days, 19% of patients had local failure, 17% nodal recurrence and 11% distant failure. Within a delay of 50 days, no nodal or distant failure was observed and only 1 patient experienced local recurrence. Upstaging and overall survival were not significantly affected by an increased waiting time. Conclusion: For N0 patients treated with IMRT for HNSCC, waiting time around 50 days after the diagnosis was not significantly associated with an excessive risk of upstaging or recurrence.http://www.sciencedirect.com/science/article/pii/S2405630816300210Head and neck squamous-cell carcinomaIntensity modulated radiation therapyWaiting timeUpstagingLoco-regional failureQuality assurance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cédric Chevalier Aurélie Bertaut Magali Quivrin Noémie Vulquin Cédric Desandes Mireille Folia Christian Duvillard Gilles Truc Gilles Crehange Philippe Maingon |
spellingShingle |
Cédric Chevalier Aurélie Bertaut Magali Quivrin Noémie Vulquin Cédric Desandes Mireille Folia Christian Duvillard Gilles Truc Gilles Crehange Philippe Maingon Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy Clinical and Translational Radiation Oncology Head and neck squamous-cell carcinoma Intensity modulated radiation therapy Waiting time Upstaging Loco-regional failure Quality assurance |
author_facet |
Cédric Chevalier Aurélie Bertaut Magali Quivrin Noémie Vulquin Cédric Desandes Mireille Folia Christian Duvillard Gilles Truc Gilles Crehange Philippe Maingon |
author_sort |
Cédric Chevalier |
title |
Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy |
title_short |
Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy |
title_full |
Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy |
title_fullStr |
Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy |
title_full_unstemmed |
Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy |
title_sort |
impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy |
publisher |
Elsevier |
series |
Clinical and Translational Radiation Oncology |
issn |
2405-6308 |
publishDate |
2016-12-01 |
description |
Background and purpose: To evaluate the influence of delays for radiotherapy on survival, recurrence and upstaging for head and neck squamous-cell carcinoma (HNSCC) with no nodal involvement treated with intensity modulated radiotherapy (IMRT).
Material and methods: This retrospective study included 63 consecutive patients with HNSCC located in the pharynx and larynx and treated with exclusive IMRT with or without chemotherapy. Survival, loco-regional or distant failure and upstaging were analyzed according to the waiting time.
Results: Mean waiting time for treatment was 62.5 days for the hypopharynx subgroup (range = 37–102), 63 days for the larynx subgroup (range = 19–128) and 58.5 days for the oropharynx subgroup (range = 29–99) (p = 0.725). Nine patients (14%) experienced upstaging. Loco-regional or distant failure occurred in 18 patients. Beyond a delay of 50 days, 19% of patients had local failure, 17% nodal recurrence and 11% distant failure. Within a delay of 50 days, no nodal or distant failure was observed and only 1 patient experienced local recurrence. Upstaging and overall survival were not significantly affected by an increased waiting time.
Conclusion: For N0 patients treated with IMRT for HNSCC, waiting time around 50 days after the diagnosis was not significantly associated with an excessive risk of upstaging or recurrence. |
topic |
Head and neck squamous-cell carcinoma Intensity modulated radiation therapy Waiting time Upstaging Loco-regional failure Quality assurance |
url |
http://www.sciencedirect.com/science/article/pii/S2405630816300210 |
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