High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis
Objectives: To determine the effect of anti-tuberculin antibodies in the T-cell proliferation in response to tuberculin and Candida antigens in individuals with different levels of tuberculosis (TB) risk. Methods: Sixteen high-risk TB individuals, 30 with an intermediate TB risk (group A), and 45 wi...
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doaj-b3be22d50d3544bf96d2867de2b2b3d42020-11-24T22:40:53ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112016-02-0143C212410.1016/j.ijid.2015.12.004High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosisEdmond J. Feris0Liliana Encinales1Carlos Awad2Joel N.H. Stern3Inna Tabansky4Luis Jiménez-Alvarez5Gustavo Ramírez-Martínez6Alfredo Cruz-Lagunas7Karen Bobadilla8Eduardo Márquez9Julio Granados-Montiel10Tatiana S. Rodriguez-Reyna11Marcelo Fernandez-Vina12Julio Granados13Joaquin Zuñiga14Edmond J. Yunis15Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USADepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USAHospital Santa Clara, Bogotá, ColombiaDepartments of Neurology and Science Education, Hofstra Northwell School of Medicine, Hempstead, New York, USAThe Rockefeller University, New York, USADepartment of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoTissue Engineering, Cell Therapy and Regenerative Medicine Research Unit, Instituto Nacional de Rehabilitación, Mexico City, MexicoDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USADepartment of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoDepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USAObjectives: To determine the effect of anti-tuberculin antibodies in the T-cell proliferation in response to tuberculin and Candida antigens in individuals with different levels of tuberculosis (TB) risk. Methods: Sixteen high-risk TB individuals, 30 with an intermediate TB risk (group A), and 45 with a low TB risk (group B), as well as 49 control individuals, were studied. Tuberculin skin test (TST) results were analyzed and serum levels of antibodies (IgG and IgM) against purified protein derivative (PPD) were measured by ELISA. Tuberculin and Candida antigens were used to stimulate T-cell proliferation in the presence of human AB serum or autologous serum. Results: High levels of anti-tuberculin IgG antibodies were found to be significantly associated with the blocking of T-cell proliferation responses in cultures stimulated with tuberculin but not with Candida antigens in the presence of autologous serum. This phenomenon was particularly frequent in high-risk individuals with high levels of anti-tuberculin IgG antibodies in the autologous serum when compared to the other risk groups, which exhibited lower levels of anti-tuberculin antibodies. Conclusions: Although cellular immunity plays a central role in the protection against TB, humoral immunity is critical in the control of Mycobacterium tuberculosis infection in high-risk individuals with latent TB infection.http://www.sciencedirect.com/science/article/pii/S1201971215002854TuberculosisMycobacterium tuberculosisLatent tuberculosisHumoral immunityAnti-tuberculin antibodiesT-cell proliferation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Edmond J. Feris Liliana Encinales Carlos Awad Joel N.H. Stern Inna Tabansky Luis Jiménez-Alvarez Gustavo Ramírez-Martínez Alfredo Cruz-Lagunas Karen Bobadilla Eduardo Márquez Julio Granados-Montiel Tatiana S. Rodriguez-Reyna Marcelo Fernandez-Vina Julio Granados Joaquin Zuñiga Edmond J. Yunis |
spellingShingle |
Edmond J. Feris Liliana Encinales Carlos Awad Joel N.H. Stern Inna Tabansky Luis Jiménez-Alvarez Gustavo Ramírez-Martínez Alfredo Cruz-Lagunas Karen Bobadilla Eduardo Márquez Julio Granados-Montiel Tatiana S. Rodriguez-Reyna Marcelo Fernandez-Vina Julio Granados Joaquin Zuñiga Edmond J. Yunis High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis International Journal of Infectious Diseases Tuberculosis Mycobacterium tuberculosis Latent tuberculosis Humoral immunity Anti-tuberculin antibodies T-cell proliferation |
author_facet |
Edmond J. Feris Liliana Encinales Carlos Awad Joel N.H. Stern Inna Tabansky Luis Jiménez-Alvarez Gustavo Ramírez-Martínez Alfredo Cruz-Lagunas Karen Bobadilla Eduardo Márquez Julio Granados-Montiel Tatiana S. Rodriguez-Reyna Marcelo Fernandez-Vina Julio Granados Joaquin Zuñiga Edmond J. Yunis |
author_sort |
Edmond J. Feris |
title |
High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis |
title_short |
High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis |
title_full |
High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis |
title_fullStr |
High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis |
title_full_unstemmed |
High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis |
title_sort |
high levels of anti-tuberculin (igg) antibodies correlate with the blocking of t-cell proliferation in individuals with high exposure to mycobacterium tuberculosis |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 1878-3511 |
publishDate |
2016-02-01 |
description |
Objectives: To determine the effect of anti-tuberculin antibodies in the T-cell proliferation in response to tuberculin and Candida antigens in individuals with different levels of tuberculosis (TB) risk.
Methods: Sixteen high-risk TB individuals, 30 with an intermediate TB risk (group A), and 45 with a low TB risk (group B), as well as 49 control individuals, were studied. Tuberculin skin test (TST) results were analyzed and serum levels of antibodies (IgG and IgM) against purified protein derivative (PPD) were measured by ELISA. Tuberculin and Candida antigens were used to stimulate T-cell proliferation in the presence of human AB serum or autologous serum.
Results: High levels of anti-tuberculin IgG antibodies were found to be significantly associated with the blocking of T-cell proliferation responses in cultures stimulated with tuberculin but not with Candida antigens in the presence of autologous serum. This phenomenon was particularly frequent in high-risk individuals with high levels of anti-tuberculin IgG antibodies in the autologous serum when compared to the other risk groups, which exhibited lower levels of anti-tuberculin antibodies.
Conclusions: Although cellular immunity plays a central role in the protection against TB, humoral immunity is critical in the control of Mycobacterium tuberculosis infection in high-risk individuals with latent TB infection. |
topic |
Tuberculosis Mycobacterium tuberculosis Latent tuberculosis Humoral immunity Anti-tuberculin antibodies T-cell proliferation |
url |
http://www.sciencedirect.com/science/article/pii/S1201971215002854 |
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