Synthesis and biological activities of some fused pyran derivatives
Ethyl benzoylacetate (1) reacted with 2-benzylidenemalanonitrile to afford the corresponding pyrane derivative (2). The latter compound reacted with 2-benzylidenemalanonitrile, carbon disulfide, formamide and benzylidene cyclohexanone, respectively, to afford the corresponding pyrano derivatives (3–...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2016-11-01
|
Series: | Arabian Journal of Chemistry |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535211002693 |
id |
doaj-b3c6d29d1639470fa60277f3edf10b0a |
---|---|
record_format |
Article |
spelling |
doaj-b3c6d29d1639470fa60277f3edf10b0a2020-11-24T23:04:29ZengElsevierArabian Journal of Chemistry1878-53522016-11-019S2S966S97010.1016/j.arabjc.2011.10.008Synthesis and biological activities of some fused pyran derivativesWesam S. ShehabAmira A. GhoneimEthyl benzoylacetate (1) reacted with 2-benzylidenemalanonitrile to afford the corresponding pyrane derivative (2). The latter compound reacted with 2-benzylidenemalanonitrile, carbon disulfide, formamide and benzylidene cyclohexanone, respectively, to afford the corresponding pyrano derivatives (3–6). Compound 2 reacted with ethyl chloroacetate to give compound (8) which cyclized to compound (9) in the presence of sodium ethoxide. Treatment of compound (2) with acetic acid in the presence of sulfuric acid afforded compound (7) which converted to compound (10) when reacted with ethylchloroacetate. Compound (10) reacted with sodium ethoxide to give compound (11). The structure of the newly synthesized compounds has been established on the basis of their analytical and spectral data.http://www.sciencedirect.com/science/article/pii/S1878535211002693PyranAminopyrancarbonitrileBenzylidenemalononitrile |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wesam S. Shehab Amira A. Ghoneim |
spellingShingle |
Wesam S. Shehab Amira A. Ghoneim Synthesis and biological activities of some fused pyran derivatives Arabian Journal of Chemistry Pyran Aminopyrancarbonitrile Benzylidenemalononitrile |
author_facet |
Wesam S. Shehab Amira A. Ghoneim |
author_sort |
Wesam S. Shehab |
title |
Synthesis and biological activities of some fused pyran derivatives |
title_short |
Synthesis and biological activities of some fused pyran derivatives |
title_full |
Synthesis and biological activities of some fused pyran derivatives |
title_fullStr |
Synthesis and biological activities of some fused pyran derivatives |
title_full_unstemmed |
Synthesis and biological activities of some fused pyran derivatives |
title_sort |
synthesis and biological activities of some fused pyran derivatives |
publisher |
Elsevier |
series |
Arabian Journal of Chemistry |
issn |
1878-5352 |
publishDate |
2016-11-01 |
description |
Ethyl benzoylacetate (1) reacted with 2-benzylidenemalanonitrile to afford the corresponding pyrane derivative (2). The latter compound reacted with 2-benzylidenemalanonitrile, carbon disulfide, formamide and benzylidene cyclohexanone, respectively, to afford the corresponding pyrano derivatives (3–6). Compound 2 reacted with ethyl chloroacetate to give compound (8) which cyclized to compound (9) in the presence of sodium ethoxide. Treatment of compound (2) with acetic acid in the presence of sulfuric acid afforded compound (7) which converted to compound (10) when reacted with ethylchloroacetate. Compound (10) reacted with sodium ethoxide to give compound (11). The structure of the newly synthesized compounds has been established on the basis of their analytical and spectral data. |
topic |
Pyran Aminopyrancarbonitrile Benzylidenemalononitrile |
url |
http://www.sciencedirect.com/science/article/pii/S1878535211002693 |
work_keys_str_mv |
AT wesamsshehab synthesisandbiologicalactivitiesofsomefusedpyranderivatives AT amiraaghoneim synthesisandbiologicalactivitiesofsomefusedpyranderivatives |
_version_ |
1725630103824629760 |