Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament...

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Main Authors: Ajani Olayinka O., Nlebemuo Martins T., Adekoya Joseph A., Ogunniran Kehinde O., Siyanbola Tolutope O., Ajanaku Christiana O.
Format: Article
Language:English
Published: Sciendo 2019-06-01
Series:Acta Pharmaceutica
Subjects:
quinoxaline
anticancer activity
pharmacophore
Online Access:https://doi.org/10.2478/acph-2019-0013
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spelling doaj-b3cb781af27e44a9927fb6a2cf3933ab2021-09-06T19:40:59ZengSciendoActa Pharmaceutica1846-95582019-06-0169217719610.2478/acph-2019-0013acph-2019-0013Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agentsAjani Olayinka O.0Nlebemuo Martins T.1Adekoya Joseph A.2Ogunniran Kehinde O.3Siyanbola Tolutope O.4Ajanaku Christiana O.5Department of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaSurpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable intermediates in drug discovery because they have been established to possess diverse pharmacological potentials. Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development.https://doi.org/10.2478/acph-2019-0013quinoxalineanticancer activitypharmacophore
collection DOAJ
language English
format Article
sources DOAJ
author Ajani Olayinka O.
Nlebemuo Martins T.
Adekoya Joseph A.
Ogunniran Kehinde O.
Siyanbola Tolutope O.
Ajanaku Christiana O.
spellingShingle Ajani Olayinka O.
Nlebemuo Martins T.
Adekoya Joseph A.
Ogunniran Kehinde O.
Siyanbola Tolutope O.
Ajanaku Christiana O.
Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
Acta Pharmaceutica
quinoxaline
anticancer activity
pharmacophore
author_facet Ajani Olayinka O.
Nlebemuo Martins T.
Adekoya Joseph A.
Ogunniran Kehinde O.
Siyanbola Tolutope O.
Ajanaku Christiana O.
author_sort Ajani Olayinka O.
title Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
title_short Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
title_full Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
title_fullStr Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
title_full_unstemmed Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
title_sort chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
publisher Sciendo
series Acta Pharmaceutica
issn 1846-9558
publishDate 2019-06-01
description Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable intermediates in drug discovery because they have been established to possess diverse pharmacological potentials. Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development.
topic quinoxaline
anticancer activity
pharmacophore
url https://doi.org/10.2478/acph-2019-0013
work_keys_str_mv AT ajaniolayinkao chemistryandpharmacologicaldiversityofquinoxalinemotifsasanticanceragents
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