The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease
Aim. The purpose of this study is to determine the association between eotaxin 426 C/T, −384 A/G, 67 G/A, eNOS −786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. Methods. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically...
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doaj-b3d04821ed2e4df7baac6acdea5130f62020-11-24T21:24:41ZengHindawi LimitedDisease Markers0278-02401875-86302015-01-01201510.1155/2015/232048232048The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery DiseaseVladimír Kincl0Jan Máchal1Adéla Drozdová2Roman Panovský3Anna Vašků4Department of Internal Medicine/Cardioangiology and ICRC, St. Anne’s University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech RepublicDepartment of Internal Medicine/Cardioangiology and ICRC, St. Anne’s University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech RepublicDepartment of Internal Medicine/Cardioangiology and ICRC, St. Anne’s University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech RepublicDepartment of Internal Medicine/Cardioangiology and ICRC, St. Anne’s University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech RepublicDepartment of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech RepublicAim. The purpose of this study is to determine the association between eotaxin 426 C/T, −384 A/G, 67 G/A, eNOS −786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. Methods. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation. Results. The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin −384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35–5.85), p=0.006; HR (95% CI) 2.63 (1.19–5.83), p=0.017; eotaxin −384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease. Conclusion. The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.http://dx.doi.org/10.1155/2015/232048 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vladimír Kincl Jan Máchal Adéla Drozdová Roman Panovský Anna Vašků |
spellingShingle |
Vladimír Kincl Jan Máchal Adéla Drozdová Roman Panovský Anna Vašků The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease Disease Markers |
author_facet |
Vladimír Kincl Jan Máchal Adéla Drozdová Roman Panovský Anna Vašků |
author_sort |
Vladimír Kincl |
title |
The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease |
title_short |
The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease |
title_full |
The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease |
title_fullStr |
The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease |
title_full_unstemmed |
The Relation between eNOS −786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, −384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease |
title_sort |
relation between enos −786 c/t, 4 a/b, mmp-13 rs640198 g/t, eotaxin 426 c/t, −384 a/g, and 67 g/a polymorphisms and long-term outcome in patients with coronary artery disease |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2015-01-01 |
description |
Aim. The purpose of this study is to determine the association between eotaxin 426 C/T, −384 A/G, 67 G/A, eNOS −786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. Methods. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation. Results. The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin −384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35–5.85), p=0.006; HR (95% CI) 2.63 (1.19–5.83), p=0.017; eotaxin −384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease. Conclusion. The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients. |
url |
http://dx.doi.org/10.1155/2015/232048 |
work_keys_str_mv |
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