Animal Models in Microbeam Radiation Therapy: A Scoping Review
Background: Microbeam Radiation Therapy (MRT) is an innovative approach in radiation oncology where a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose beams which are tens of micrometres wide and separated by a few hundred micrometres. Objective: This scopi...
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doaj-b3d20227d3e74b658c7102aaf58aea8e2020-11-25T02:16:18ZengMDPI AGCancers2072-66942020-02-0112352710.3390/cancers12030527cancers12030527Animal Models in Microbeam Radiation Therapy: A Scoping ReviewCristian Fernandez-Palomo0Jennifer Fazzari1Verdiana Trappetti2Lloyd Smyth3Heidrun Janka4Jean Laissue5Valentin Djonov6Institute of Anatomy, University of Bern, 3012 Bern, SwitzerlandInstitute of Anatomy, University of Bern, 3012 Bern, SwitzerlandInstitute of Anatomy, University of Bern, 3012 Bern, SwitzerlandDepartment of Obstetrics & Gynaecology, University of Melbourne, 3057 Parkville, AustraliaMedical Library, University Library Bern, University of Bern, 3012 Bern, SwitzerlandInstitute of Anatomy, University of Bern, 3012 Bern, SwitzerlandInstitute of Anatomy, University of Bern, 3012 Bern, SwitzerlandBackground: Microbeam Radiation Therapy (MRT) is an innovative approach in radiation oncology where a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose beams which are tens of micrometres wide and separated by a few hundred micrometres. Objective: This scoping review was conducted to map the available evidence and provide a comprehensive overview of the similarities, differences, and outcomes of all experiments that have employed animal models in MRT. Methods: We considered articles that employed animal models for the purpose of studying the effects of MRT. We searched in seven databases for published and unpublished literature. Two independent reviewers screened citations for inclusion. Data extraction was done by three reviewers. Results: After screening 5688 citations and 159 full-text papers, 95 articles were included, of which 72 were experimental articles. Here we present the animal models and pre-clinical radiation parameters employed in the existing MRT literature according to their use in cancer treatment, non-neoplastic diseases, or normal tissue studies. Conclusions: The study of MRT is concentrated in brain-related diseases performed mostly in rat models. An appropriate comparison between MRT and conventional radiotherapy (instead of synchrotron broad beam) is needed. Recommendations are provided for future studies involving MRT.https://www.mdpi.com/2072-6694/12/3/527microbeam radiation therapyscoping reviewanimal modelsratmousesynchrotronspatial fractionationradiotherapyoncology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cristian Fernandez-Palomo Jennifer Fazzari Verdiana Trappetti Lloyd Smyth Heidrun Janka Jean Laissue Valentin Djonov |
spellingShingle |
Cristian Fernandez-Palomo Jennifer Fazzari Verdiana Trappetti Lloyd Smyth Heidrun Janka Jean Laissue Valentin Djonov Animal Models in Microbeam Radiation Therapy: A Scoping Review Cancers microbeam radiation therapy scoping review animal models rat mouse synchrotron spatial fractionation radiotherapy oncology |
author_facet |
Cristian Fernandez-Palomo Jennifer Fazzari Verdiana Trappetti Lloyd Smyth Heidrun Janka Jean Laissue Valentin Djonov |
author_sort |
Cristian Fernandez-Palomo |
title |
Animal Models in Microbeam Radiation Therapy: A Scoping Review |
title_short |
Animal Models in Microbeam Radiation Therapy: A Scoping Review |
title_full |
Animal Models in Microbeam Radiation Therapy: A Scoping Review |
title_fullStr |
Animal Models in Microbeam Radiation Therapy: A Scoping Review |
title_full_unstemmed |
Animal Models in Microbeam Radiation Therapy: A Scoping Review |
title_sort |
animal models in microbeam radiation therapy: a scoping review |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-02-01 |
description |
Background: Microbeam Radiation Therapy (MRT) is an innovative approach in radiation oncology where a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose beams which are tens of micrometres wide and separated by a few hundred micrometres. Objective: This scoping review was conducted to map the available evidence and provide a comprehensive overview of the similarities, differences, and outcomes of all experiments that have employed animal models in MRT. Methods: We considered articles that employed animal models for the purpose of studying the effects of MRT. We searched in seven databases for published and unpublished literature. Two independent reviewers screened citations for inclusion. Data extraction was done by three reviewers. Results: After screening 5688 citations and 159 full-text papers, 95 articles were included, of which 72 were experimental articles. Here we present the animal models and pre-clinical radiation parameters employed in the existing MRT literature according to their use in cancer treatment, non-neoplastic diseases, or normal tissue studies. Conclusions: The study of MRT is concentrated in brain-related diseases performed mostly in rat models. An appropriate comparison between MRT and conventional radiotherapy (instead of synchrotron broad beam) is needed. Recommendations are provided for future studies involving MRT. |
topic |
microbeam radiation therapy scoping review animal models rat mouse synchrotron spatial fractionation radiotherapy oncology |
url |
https://www.mdpi.com/2072-6694/12/3/527 |
work_keys_str_mv |
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