Fibroblast Growth Factor Receptor Functions in Glioblastoma
Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma. Somatic mutations of fibrobl...
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Online Access: | https://www.mdpi.com/2073-4409/8/7/715 |
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doaj-b3d5b66c866b4b76a384e2e6279327c82020-11-24T21:27:37ZengMDPI AGCells2073-44092019-07-018771510.3390/cells8070715cells8070715Fibroblast Growth Factor Receptor Functions in GlioblastomaAna Jimenez-Pascual0Florian A. Siebzehnrubl1European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff CF24 4HQ, UKEuropean Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff CF24 4HQ, UKGlioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma. Somatic mutations of fibroblast growth factor receptors (<i>FGFRs</i>) are rare in these cancers, but many studies have documented that signaling through FGFRs impacts glioblastoma progression and patient survival. Small-molecule inhibitors of FGFR tyrosine kinases are currently being trialed, underlining the therapeutic potential of blocking this signaling pathway. Nevertheless, a comprehensive overview of the state of the art of the literature on FGFRs in glioblastoma is lacking. Here, we review the evidence for the biological functions of FGFRs in glioblastoma, as well as pharmacological approaches to targeting these receptors.https://www.mdpi.com/2073-4409/8/7/715FGFRreviewmalignant gliomabrain cancerastrocytomafibroblast growth factor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Jimenez-Pascual Florian A. Siebzehnrubl |
spellingShingle |
Ana Jimenez-Pascual Florian A. Siebzehnrubl Fibroblast Growth Factor Receptor Functions in Glioblastoma Cells FGFR review malignant glioma brain cancer astrocytoma fibroblast growth factor |
author_facet |
Ana Jimenez-Pascual Florian A. Siebzehnrubl |
author_sort |
Ana Jimenez-Pascual |
title |
Fibroblast Growth Factor Receptor Functions in Glioblastoma |
title_short |
Fibroblast Growth Factor Receptor Functions in Glioblastoma |
title_full |
Fibroblast Growth Factor Receptor Functions in Glioblastoma |
title_fullStr |
Fibroblast Growth Factor Receptor Functions in Glioblastoma |
title_full_unstemmed |
Fibroblast Growth Factor Receptor Functions in Glioblastoma |
title_sort |
fibroblast growth factor receptor functions in glioblastoma |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2019-07-01 |
description |
Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma. Somatic mutations of fibroblast growth factor receptors (<i>FGFRs</i>) are rare in these cancers, but many studies have documented that signaling through FGFRs impacts glioblastoma progression and patient survival. Small-molecule inhibitors of FGFR tyrosine kinases are currently being trialed, underlining the therapeutic potential of blocking this signaling pathway. Nevertheless, a comprehensive overview of the state of the art of the literature on FGFRs in glioblastoma is lacking. Here, we review the evidence for the biological functions of FGFRs in glioblastoma, as well as pharmacological approaches to targeting these receptors. |
topic |
FGFR review malignant glioma brain cancer astrocytoma fibroblast growth factor |
url |
https://www.mdpi.com/2073-4409/8/7/715 |
work_keys_str_mv |
AT anajimenezpascual fibroblastgrowthfactorreceptorfunctionsinglioblastoma AT florianasiebzehnrubl fibroblastgrowthfactorreceptorfunctionsinglioblastoma |
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1725974405956239360 |