| Summary: | The ionotropic glutamate receptor activated byN-methyl-D-aspartate (iGluR-NMDA) is amultiheteromeric complex constituted from bythree to five subunits belonging to by threedifferent kinds of subunits known as NR1, NR2ADy NR3A y B. It is well established the participationof iGluR-NMDA complexes in a broadrange of physiological, pathological, and as intermediaryin pharmacological processes of neuralsystems.In the CNS, iGluR-NMDA participates inlearning, memory, plasticity, neural differentiation,neural migration, and apoptosis, amongothers. In addition, from the pharmacologicalpoint of view the iGluR-NMDA is playing a rolein excitotoxicity, drugs-addiction and otherdependences. How the same complex can participatein a significant broad group of neuralactivities is a valid question after a literaturereview.A carefully analysis shows that iGluR-NMDAinteracts, at some level, with a big number ofintracellular proteins belonging to signaling proteinsfamily, support proteins, modulatorproteins, cytoskeleton, and enzymes, resultingin interactions with more than a 160 proteins, atdifferent interaction levels and acting with intracellularproteins.In this work we report a proposal for amodel of differential signaling cascade pathwaysgenerated by the iGluR-NMDA gating.The model shows at least the possibility of threedifferent signaling pathways.
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