Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness
Bronchial asthma is a chronic disease characterized by reversible airway obstruction, mucus production, and bronchial hyperresponsiveness (BHR). Although Th2 cell-mediated eosinophilic inflammation is an important disease mechanism in the majority of patients with bronchial asthma, recent studies su...
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doaj-b3e493683ef84889baba014888a108952020-11-25T01:03:33ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-06-012012298010.3390/ijms20122980ijms20122980Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial HyperresponsivenessMayumi Saeki0Tomoe Nishimura1Noriko Kitamura2Takachika Hiroi3Akio Mori4Osamu Kaminuma5Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanBronchial asthma is a chronic disease characterized by reversible airway obstruction, mucus production, and bronchial hyperresponsiveness (BHR). Although Th2 cell-mediated eosinophilic inflammation is an important disease mechanism in the majority of patients with bronchial asthma, recent studies suggest the possible development of Th2-independent airway inflammation and BHR. These non-Th2 endotype patients seem to consist of multiple subgroups, and often do not respond to inhaled corticosteroids. Therefore, to understand the pathogenesis of asthma, it is important to characterize these non-Th2 subgroups. Recently, we demonstrated that Th9 cells induce eosinophil infiltration and eosinophil-independent BHR, and Th9 cells-mediated BHR may be resistant to glucocorticoid. In this review, we summarize the contribution of several T cell subsets in the development of bronchial asthma and introduce our recent study demonstrating Th9 cell-mediated and eosinophil-independent BHR.https://www.mdpi.com/1422-0067/20/12/2980allergyasthmaairway inflammationbronchial hyper responsiveness |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mayumi Saeki Tomoe Nishimura Noriko Kitamura Takachika Hiroi Akio Mori Osamu Kaminuma |
spellingShingle |
Mayumi Saeki Tomoe Nishimura Noriko Kitamura Takachika Hiroi Akio Mori Osamu Kaminuma Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness International Journal of Molecular Sciences allergy asthma airway inflammation bronchial hyper responsiveness |
author_facet |
Mayumi Saeki Tomoe Nishimura Noriko Kitamura Takachika Hiroi Akio Mori Osamu Kaminuma |
author_sort |
Mayumi Saeki |
title |
Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness |
title_short |
Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness |
title_full |
Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness |
title_fullStr |
Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness |
title_full_unstemmed |
Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness |
title_sort |
potential mechanisms of t cell-mediated and eosinophil-independent bronchial hyperresponsiveness |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-06-01 |
description |
Bronchial asthma is a chronic disease characterized by reversible airway obstruction, mucus production, and bronchial hyperresponsiveness (BHR). Although Th2 cell-mediated eosinophilic inflammation is an important disease mechanism in the majority of patients with bronchial asthma, recent studies suggest the possible development of Th2-independent airway inflammation and BHR. These non-Th2 endotype patients seem to consist of multiple subgroups, and often do not respond to inhaled corticosteroids. Therefore, to understand the pathogenesis of asthma, it is important to characterize these non-Th2 subgroups. Recently, we demonstrated that Th9 cells induce eosinophil infiltration and eosinophil-independent BHR, and Th9 cells-mediated BHR may be resistant to glucocorticoid. In this review, we summarize the contribution of several T cell subsets in the development of bronchial asthma and introduce our recent study demonstrating Th9 cell-mediated and eosinophil-independent BHR. |
topic |
allergy asthma airway inflammation bronchial hyper responsiveness |
url |
https://www.mdpi.com/1422-0067/20/12/2980 |
work_keys_str_mv |
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