Bufalin Alters Gene Expressions Associated DNA Damage, Cell Cycle, and Apoptosis in Human Lung Cancer NCI-H460 Cells in Vitro

Bufalin Alters Gene Expressions Associated DNA Damage, Cell Cycle, and Apoptosis in Human Lung Cancer NCI-H460 Cells in Vitro

Lung cancer is the leading cause of cancer related death and there is no effective treatment to date. Bufalin has been shown effective in inducing apoptosis and DNA damage in lung cancer cells. However, the genetic mechanisms underlying these actions have not been elucidated yet. Cultured NCI-H460 c...

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Bibliographic Details
Main Authors: Shin-Hwar Wu, Yung-Ting Hsiao, Jaw-Chyum Chen, Ju-Hwa Lin, Shu-Chun Hsu, Te-Chun Hsia, Su-Tso Yang, Wu-Huei Hsu, Jing-Gung Chung
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
bufalin
cDNA microarray
DNA damage
cell cycle
apoptosis
NCI-H460 cells
Online Access:http://www.mdpi.com/1420-3049/19/5/6047

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