Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages
The localization of lipoprotein lipase (LPL) in human atherosclerotic lesions was studied with immunocytochemical techniques. In the fibrous cap and surrounding intima of the plaque, where the smooth muscle cell is the dominating cell type, a high number of cells reacted with anti-LPL. A much lower...
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1987-04-01
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Series: | Journal of Lipid Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520386946 |
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doaj-b3f3d8878fee49569675ecce5a88ff2c2021-04-25T04:20:34ZengElsevierJournal of Lipid Research0022-22751987-04-01284437445Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophagesL JonassonG BondjersG K HanssonThe localization of lipoprotein lipase (LPL) in human atherosclerotic lesions was studied with immunocytochemical techniques. In the fibrous cap and surrounding intima of the plaque, where the smooth muscle cell is the dominating cell type, a high number of cells reacted with anti-LPL. A much lower number of stained cells was seen in the central lipid core region where the macrophages dominate. Further characterization of the LPL-containing cells in tissue sections showed that most of them were smooth muscle cells. Only a minor fraction of the macrophages in the plaque contained the enzyme. The results were confirmed on isolated cells from atherosclerotic tissue. Lipoprotein lipase was also detected in smooth muscle cells of non-atherosclerotic arteries. These findings suggest that the smooth muscle cells are the major source of LPL in the vascular wall. However, the enzyme was not present in some of the smooth muscle cells in the atherosclerotic lesion. This may imply that LPL synthesis is down-regulated in the atherosclerotic plaque.http://www.sciencedirect.com/science/article/pii/S0022227520386946 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
L Jonasson G Bondjers G K Hansson |
spellingShingle |
L Jonasson G Bondjers G K Hansson Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages Journal of Lipid Research |
author_facet |
L Jonasson G Bondjers G K Hansson |
author_sort |
L Jonasson |
title |
Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages |
title_short |
Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages |
title_full |
Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages |
title_fullStr |
Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages |
title_full_unstemmed |
Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages |
title_sort |
lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
1987-04-01 |
description |
The localization of lipoprotein lipase (LPL) in human atherosclerotic lesions was studied with immunocytochemical techniques. In the fibrous cap and surrounding intima of the plaque, where the smooth muscle cell is the dominating cell type, a high number of cells reacted with anti-LPL. A much lower number of stained cells was seen in the central lipid core region where the macrophages dominate. Further characterization of the LPL-containing cells in tissue sections showed that most of them were smooth muscle cells. Only a minor fraction of the macrophages in the plaque contained the enzyme. The results were confirmed on isolated cells from atherosclerotic tissue. Lipoprotein lipase was also detected in smooth muscle cells of non-atherosclerotic arteries. These findings suggest that the smooth muscle cells are the major source of LPL in the vascular wall. However, the enzyme was not present in some of the smooth muscle cells in the atherosclerotic lesion. This may imply that LPL synthesis is down-regulated in the atherosclerotic plaque. |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520386946 |
work_keys_str_mv |
AT ljonasson lipoproteinlipaseinatherosclerosisitspresenceinsmoothmusclecellsandabsencefrommacrophages AT gbondjers lipoproteinlipaseinatherosclerosisitspresenceinsmoothmusclecellsandabsencefrommacrophages AT gkhansson lipoproteinlipaseinatherosclerosisitspresenceinsmoothmusclecellsandabsencefrommacrophages |
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