N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells

N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells

Early growth response-1 (Egr-1), a transcription factor which often underlies the molecular basis of myocardial ischemia/reperfusion (I/R) injury, and oxidative stress, is key to myocardial I/R injury. Silent information regulator of transcription 1(SIRT1) not only interacts with and is inhibited by...

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Bibliographic Details
Main Authors: Ting Sun, Yanmei Zhang, Shuping Zhong, Fenfei Gao, Yicun Chen, Bin Wang, Wenfeng Cai, Zhaojing Zhang, Weiqiu Li, Shishi Lu, Fuchun Zheng, Ganggang Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
N-n-butyl haloperidol
reactive oxygen species
Egr-1
SIRT1
hypoxia/reoxygenation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00019/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00019/full

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