Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases

Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases

Non-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation capabilities such as the heart. The role of regulatory networks m...

Full description

Bibliographic Details
Main Authors: André F. Gabriel, Marina C. Costa, Francisco J. Enguita
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
non-coding rna
circrnas
mirnas
cardiovascular diseases
rna regulatory networks
Online Access:https://www.mdpi.com/1422-0067/21/2/456
id doaj-b4043faf4a67485abea847bcdab36e86
record_format Article
spelling doaj-b4043faf4a67485abea847bcdab36e862020-11-25T00:35:15ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-01-0121245610.3390/ijms21020456ijms21020456Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular DiseasesAndré F. Gabriel0Marina C. Costa1Francisco J. Enguita2Instituto de Medicina, Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, PortugalInstituto de Medicina, Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, PortugalInstituto de Medicina, Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, PortugalNon-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation capabilities such as the heart. The role of regulatory networks mediated by non-coding RNAs in the pathophysiology of cardiovascular conditions is starting to be unveiled. However, a deeper knowledge of the functional interactions among the diverse non-coding RNA families and their phenotypic consequences is required. This review presents the current knowledge about the functional crosstalk between circRNAs and other biomolecules in the framework of the cardiovascular diseases.https://www.mdpi.com/1422-0067/21/2/456non-coding rnacircrnasmirnascardiovascular diseasesrna regulatory networks
collection DOAJ
language English
format Article
sources DOAJ
author André F. Gabriel
Marina C. Costa
Francisco J. Enguita
spellingShingle André F. Gabriel
Marina C. Costa
Francisco J. Enguita
Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases
International Journal of Molecular Sciences
non-coding rna
circrnas
mirnas
cardiovascular diseases
rna regulatory networks
author_facet André F. Gabriel
Marina C. Costa
Francisco J. Enguita
author_sort André F. Gabriel
title Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases
title_short Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases
title_full Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases
title_fullStr Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases
title_full_unstemmed Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases
title_sort circular rna-centered regulatory networks in the physiopathology of cardiovascular diseases
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2020-01-01
description Non-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation capabilities such as the heart. The role of regulatory networks mediated by non-coding RNAs in the pathophysiology of cardiovascular conditions is starting to be unveiled. However, a deeper knowledge of the functional interactions among the diverse non-coding RNA families and their phenotypic consequences is required. This review presents the current knowledge about the functional crosstalk between circRNAs and other biomolecules in the framework of the cardiovascular diseases.
topic non-coding rna
circrnas
mirnas
cardiovascular diseases
rna regulatory networks
url https://www.mdpi.com/1422-0067/21/2/456
work_keys_str_mv AT andrefgabriel circularrnacenteredregulatorynetworksinthephysiopathologyofcardiovasculardiseases
AT marinaccosta circularrnacenteredregulatorynetworksinthephysiopathologyofcardiovasculardiseases
AT franciscojenguita circularrnacenteredregulatorynetworksinthephysiopathologyofcardiovasculardiseases
_version_ 1725309496846188544

Similar Items