Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages

The role of the genome structure in the establishment of the embryonic and trophoblast lineages is still not well understood. Here the authors perform promoter capture Hi-C in mouse trophoblast and embryonic stem cells and find divergent networks of repressive and active chromatin interactions betwe...

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Main Authors:	Stefan Schoenfelder, Borbala Mifsud, Claire E. Senner, Christopher D. Todd, Stephanie Chrysanthou, Elodie Darbo, Myriam Hemberger, Miguel R. Branco
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06666-4

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spelling	doaj-b406d78bb61b40df9e736ae3f1f1e49a2021-05-11T10:12:04ZengNature Publishing GroupNature Communications2041-17232018-10-019111010.1038/s41467-018-06666-4Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineagesStefan Schoenfelder0Borbala Mifsud1Claire E. Senner2Christopher D. Todd3Stephanie Chrysanthou4Elodie Darbo5Myriam Hemberger6Miguel R. Branco7Nuclear Dynamics Programme, Babraham InstituteWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, QMULEpigenetics Programme, Babraham InstituteBlizard Institute, Barts and The London School of Medicine and Dentistry, QMULEpigenetics Programme, Babraham InstituteBordeaux Bioinformatics CenterEpigenetics Programme, Babraham InstituteBlizard Institute, Barts and The London School of Medicine and Dentistry, QMULThe role of the genome structure in the establishment of the embryonic and trophoblast lineages is still not well understood. Here the authors perform promoter capture Hi-C in mouse trophoblast and embryonic stem cells and find divergent networks of repressive and active chromatin interactions between the two lineages.https://doi.org/10.1038/s41467-018-06666-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stefan Schoenfelder Borbala Mifsud Claire E. Senner Christopher D. Todd Stephanie Chrysanthou Elodie Darbo Myriam Hemberger Miguel R. Branco
spellingShingle	Stefan Schoenfelder Borbala Mifsud Claire E. Senner Christopher D. Todd Stephanie Chrysanthou Elodie Darbo Myriam Hemberger Miguel R. Branco Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages Nature Communications
author_facet	Stefan Schoenfelder Borbala Mifsud Claire E. Senner Christopher D. Todd Stephanie Chrysanthou Elodie Darbo Myriam Hemberger Miguel R. Branco
author_sort	Stefan Schoenfelder
title	Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
title_short	Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
title_full	Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
title_fullStr	Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
title_full_unstemmed	Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
title_sort	divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	The role of the genome structure in the establishment of the embryonic and trophoblast lineages is still not well understood. Here the authors perform promoter capture Hi-C in mouse trophoblast and embryonic stem cells and find divergent networks of repressive and active chromatin interactions between the two lineages.
url	https://doi.org/10.1038/s41467-018-06666-4
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Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages

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