The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review
Background: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. Thi...
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doaj-b408b6580de04ad0876b490afc2e5b7e2020-11-24T21:56:56ZengMDPI AGNutrients2072-66432017-04-019542910.3390/nu9050429nu9050429The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic ReviewNeil Bernard Boyle0Clare Lawton1Louise Dye2School of Psychology, University of Leeds, Leeds LS2 9JT, UKSchool of Psychology, University of Leeds, Leeds LS2 9JT, UKSchool of Psychology, University of Leeds, Leeds LS2 9JT, UKBackground: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. Methods: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016. Ovid Medline, PsychInfo, Embase, CINAHL and Cochrane databases were searched using equivalent search terms. A grey literature review of relevant sources was also undertaken. Results: 18 studies were included in the review. All reviewed studies recruited samples based upon an existing vulnerability to anxiety: mildly anxious, premenstrual syndrome (PMS), postpartum status, and hypertension. Four/eight studies in anxious samples, four/seven studies in PMS samples, and one/two studies in hypertensive samples reported positive effects of Mg on subjective anxiety outcomes. Mg had no effect on postpartum anxiety. No study administered a validated measure of subjective stress as an outcome. Conclusions: Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples. However, the quality of the existing evidence is poor. Well-designed randomised controlled trials are required to further confirm the efficacy of Mg supplementation.http://www.mdpi.com/2072-6643/9/5/429magnesiumanxietystressintervention |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neil Bernard Boyle Clare Lawton Louise Dye |
spellingShingle |
Neil Bernard Boyle Clare Lawton Louise Dye The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review Nutrients magnesium anxiety stress intervention |
author_facet |
Neil Bernard Boyle Clare Lawton Louise Dye |
author_sort |
Neil Bernard Boyle |
title |
The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review |
title_short |
The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review |
title_full |
The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review |
title_fullStr |
The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review |
title_full_unstemmed |
The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review |
title_sort |
effects of magnesium supplementation on subjective anxiety and stress—a systematic review |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2017-04-01 |
description |
Background: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. Methods: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016. Ovid Medline, PsychInfo, Embase, CINAHL and Cochrane databases were searched using equivalent search terms. A grey literature review of relevant sources was also undertaken. Results: 18 studies were included in the review. All reviewed studies recruited samples based upon an existing vulnerability to anxiety: mildly anxious, premenstrual syndrome (PMS), postpartum status, and hypertension. Four/eight studies in anxious samples, four/seven studies in PMS samples, and one/two studies in hypertensive samples reported positive effects of Mg on subjective anxiety outcomes. Mg had no effect on postpartum anxiety. No study administered a validated measure of subjective stress as an outcome. Conclusions: Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples. However, the quality of the existing evidence is poor. Well-designed randomised controlled trials are required to further confirm the efficacy of Mg supplementation. |
topic |
magnesium anxiety stress intervention |
url |
http://www.mdpi.com/2072-6643/9/5/429 |
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