Titin-Isoform Dependence of Titin-Actin Interaction and Its Regulation by S100A1/Ca2+ in Skinned Myocardium
Titin, also known as connectin, is a large filamentous protein that greatly contributes to passive myocardial stiffness. In vitro evidence suggests that one of titin's spring elements, the PEVK, interacts with actin and that this adds a viscous component to passive stiffness. Differential splic...
Main Authors: | Hideto Fukushima, Charles S. Chung, Henk Granzier |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2010-01-01
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Series: | Journal of Biomedicine and Biotechnology |
Online Access: | http://dx.doi.org/10.1155/2010/727239 |
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